THERAPEUTIC CLASS
Octreotide for hypoglycemia caused by sulfonylurea and DPP-4 inhibitor
We describe a type 2 diabetes patient with persistent hypoglycemia caused by sulfonylurea
misuse on top of a DPP-4 inhibitor. Hyperinsulinemia was exaggerated by dextrose administration,
but was successfully treated with octreotide. Since many patients are currently
treated with DPP-4 inhibitors, the importance of octreotide has been increasing. For
refractory sulfonylurea-induced hypoglycemia, especially when the patient is also being
given an incretin-based therapy, octreotide should be considered
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