THERAPEUTIC CLASS

Pasireotide (SOM230) Prevents Sulfonylurea-induced Hypoglycemia in Rats

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Persistent hypoglycemia is a serious condition that is frequently reported in patients undergoing
sulfonylurea treatment, often necessitating hospitalization in the event of overdose. Somatostatin is a regulatory hormone with a broad range of physiological actions that include the inhibition of insulin and glucagon secretion, predominantly via activation of the somatostatin
receptor subtypes sstr5 and sstr2, respectively.

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: .,

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Language

English

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NONE

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Subject(s)

Endocrine & Metabolic system

Specific Detail Info

Exp Clin Endocrinol Diabetes 2015;123: 193–197

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