THERAPEUTIC CLASS
Circadian phase-shifting by light: Beyond photons
Circadian entrainment to the solar light:dark schedule is thought to be maintained by a simple photon counting method. According to this hypothesis, the pacemaker adjusts the phase of the body’s endogenous rhythms in accordance to the intensity and duration with which it encounters a perceived twilight signal. While previous data have generally supported the hypothesis, more recent analysis has codified other factors besides irradiance that influence the magnitude of resetting responses to light delivered within the same phase of the circadian
cycle. In particular, the frequency with which light is alternated with darkness, or whether it’s packaged in millisecond flashes versus continuous blocks, can significantly alter the dose-response relationship.
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