THERAPEUTIC CLASS

Mineralocorticoid Antagonism and Diabetic Kidney Disease

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Type 2 diabetes (T2D) is associated with an increased risk of diabetic kidney disease (DKD), cardiovascular disease, and heart failure, in part through activation of the renin-angiotensin-aldosterone system (RAAS). Although recent cardiovascular outcome trials have identified newer therapeutic agents such as sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1)-receptor agonists that reduce the risk of these complications, patients still exhibit residual cardiorenal morbidity and mortality. Accordingly, the identification of pharmacological agents that attenuate micro- and macrovascular complications related to T2D is a major priority.

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Detail Information

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Cardiovascular & Hematopoietic System
Endocrine & Metabolic system

Specific Detail Info

Current Diabetes Reports (2019) 19:4

Statement of Responsibility

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