THERAPEUTIC CLASS

The pathogenesis of lactic acidosis in sepsis

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Lactic acidosis is a common finding in critically ill patients during severe sepsis/septic shock, and a powerful predictor of mortality. Because of the knowledge that lactate is the end product of
anaerobic glycolysis, the presence of hyperlactatemia in sepsis has been taken to indicate the
development of anaerobic glycolysis within tissues. Such anaerobic glycolysis is understood to
result from oxygen “debt” at cellular level

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: .,

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English

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NONE

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Subject(s)

Nephrology system

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