THERAPEUTIC CLASS

Tailoring Natural Killer cell immunotherapy to the tumour microenvironment

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Natural killer (NK) cells are cytotoxic and cytokine-secreting cells that can mediate potent anti-tumour activity.
Accumulating evidence indicates that NK cell functions are severely compromised within the confines of the
tumour microenvironment thus impairing the efficacy and development of NK cell-based therapies. Here we
review the various cellular and molecular pathways that tumours have supplanted to evade NK cell surveillance

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: .,

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Language

English

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NONE

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Subject(s)

Antineoplastic

Specific Detail Info

Seminars in Immunology 2017

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