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Efficacy of oral L-ornithine L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy

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Hyperammonemia and associated cerebral edema cause neurological abnormalities in liver disease patients.
Although only 15% of ammonia production originates in the colon, management strategies for hepatic encephalopathy (HE) have focused on reducing ammonia generation from the bowel rather than on manipulating systemic mechanisms involved in ammonia metabolism. administration of L-ornithine L-aspartate (LOLA) improves
mental status and decreases serum and spinal fluid ammonia levels by stimulating both the urea
cycle and glutamine (Gln) synthesis, which are key metabolic pathways in ammonia detoxification.

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Language

English

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NONE

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Lolindex

Specific Detail Info

Annals of Hepatology 2011; 10 (Suppl.2): S55-S59

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