A DISTRIBUTION STUDY WITH 14C-OTILONIUM BROMIDE IN THE RAT: EVIDENCE FOR SELECTIVE TROPISM FOR LARGE INTESTINE AFTER ORAL ADMINISTRATION

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A DISTRIBUTION STUDY WITH 14C-OTILONIUM BROMIDE IN THE RAT: EVIDENCE FOR SELECTIVE TROPISM FOR LARGE INTESTINE AFTER ORAL ADMINISTRATION

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The aim of this study was to determine the plasma levels and the tissue distribution of otilonium bromide, measured as total radioactivity, after oral administration of 2 mg/kg of 14C-labeled drug to rats. Radioactivity levels were very low in the plasma (ranging from 2.7 ng Eq/ml at 1.5 h to 0.6 ng Eq/ml at 24 h) as compared with those found in the gastrointestinal (GI) tract, indicating negligible systemic otilonium bromide absorption.

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Language: English
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Subject(s): Spasmomen
Specific Detail Info: DRUG METABOLISM AND DISPOSITION 2000;Vol. 28, No. 6:643-7
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A DISTRIBUTION STUDY WITH 14C-OTILONIUM BROMIDE IN THE RAT: EVIDENCE FOR SELECTIVE TROPISM FOR LARGE INTESTINE AFTER ORAL ADMINISTRATION

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