THERAPEUTIC CLASS

Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

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Hepatitis B virus (HBV) generally causes self-limiting infection in immunocompetent adults, but establishes chronic infection in some adults and in most maternally infected infants. Factors determining clearance versus persistence are not fully understood. Hydrodynamic injection (HDI) of HBV replicon plasmid via tail vein generally results in quick clearance in immunocompetent adult mice. Here, we report the identification of strain-specific persistence of HBV in mice: one genotype B strain, designated BPS, persisted up to 33 weeks in ~50% of HDI mice. BPS persistence requires viral replication and multiple viral features.

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: .,

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Language

English

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NONE

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LITERATURE

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SNMC
Gastrointestinal & Hepatobiliary System
HBIG
Lolindex

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