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LITERATURE

The Antihyperglycemic Drug a-Lipoic Acid Stimulates Glucose Uptake via Both GLUT4 translocation and GLUT4 Activation


The cofactor of mitochondrial dehydrogenase complexes and potent antioxidant a-lipoic acid has been shown to lower blood glucose in diabetic animals. a-Lipoic acid enhances glucose uptake and GLUT1 and GLUT4 translocation in 3T3-L1 adipocytes and L6 myotubes, mimicking insulin action.


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English
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NONE
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Diabetes 50:1464–1471, 2001
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