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Lipoic Acid Reduces the Activities of Biotin-Dependent Carboxylases in Rat Liver

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In the past, lipoic acid has been administered to patients and test animals as therapy for diabetic neuropathy and various intoxications. Lipoic acid and the vitamin biotin have structural similarities. We sought to determine whether the chronic administration of lipoic acid affects the activities of biotin-dependent carboxylases. For 28 d, rats received daily intraperitoneal injections of one of the following: 1) a small dose of lipoic acid [4.3 mmol/( kgrd)]; 2) a large dose of lipoic acid [15.6 mmol/(kgrd)]; or 3) a large dose of lipoic acid plus biotin [15.6 and 2.0 mmol/(kgrd), respectively].

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: .,

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Language

English

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NONE

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Subject(s)

Alicron

Specific Detail Info

J. Nutr. 127: 1776–1781, 1997

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