THERAPEUTIC CLASS
Acute Liver Injury and Failure
Acute liver injury (ALI) and acute liver failure (ALF) are clinical syndromes that are frequently life threatening, characterized by a rapid loss of hepatocyte function in a patient without pre-existing liver disease.1 Numerous definitions for ALF have been proposed in the published literature, most of which involve a combination of an acute onset of clinical signs, the presence of coagulopathy, icterus, and the development of hepatic encephalopathy (HE).
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