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Which is most pungent: isoflurane, sevoflurane or desflurane?


We compared the pungency and tolerability of three inhaled anaesthetics in a randomized,
double-blind study. Eighty-one unpremedicated patients (n=27, each group) inhaled 2 MAC of
isoflurane (2.3%), desflurane (12%) or sevoflurane (4%) for 60 s from an anaesthetic breathing
circuit via a mask. Two blinded observers recorded coughing, complaints of burning and irritation,
and how long the inhalation was tolerated.


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English
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NONE
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BrJAnaesth 2000; 85: 305-7
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