PRODUCT LITERATURE

Comparison of Strategies Using Cefpirome and Ceftazidime for Empiric Treatment of Pneumonia in Intensive Care Patients

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In an international, multicenter, open-label, randomized comparative study, adult patients in intensive care
units were enrolled to receive cefpirome intravenously at 2 g twice daily or ceftazidime intravenously at 2 g
three times daily for the empiric treatment of pneumonia. Randomization was performed after a double
stratification according to the investigator’s initial choice of monotherapy or combination therapy and then on
the basis of the severity of disease. The primary endpoint was the clinical response at the end of treatment in
the intent-to-treat population. Data for all patients were reviewed by a blinded observer. Of the 400 enrolled
patients, 201 received cefpirome (monotherapy, 56%) and 199 received ceftazidime (monotherapy, 51%).
Pneumonia was hospital acquired for 75% of the patients

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: .,

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Language

English

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NONE

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Subject(s)

CEFRIN

Specific Detail Info

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jan. 1998, Vol 42 No. 1 p. 28–36

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