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Efficacy dose response relationship and safety of once-daily extended-release metformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemic controlrndespite prior treatment with diet and exercise: results from two double-blind, placebo-controlled studies


The efficacy, dose–response relationships and safety of an extended-release formulation of metformin
(Glucophage1 XR) were evaluated in two double-blind, randomized, placebo-controlled studies of 24 and 16 weeks’
duration, in patients with inadequate glycaemic control despite diet and exercise. Protocol 1 provided an evaluation
of metformin XR at a commonly used dosage. Protocol 2 evaluated different dosages of metformin XR


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English
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