PRODUCT LITERATURE

Pregabalin: Its Pharmacology and Use in Pain Management

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Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter
-aminobutyric acid. It is an 2- (2-) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently
to the 2- subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available
efficacy studies in pain management

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: .,

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Language

English

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NONE

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Subject(s)

LEPTICA

Specific Detail Info

Anesth Analg 2007;105:1805–15

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