PRODUCT LITERATURE
Antibiotic-Induced Lipopolysaccharide (LPS) Release from Salmonella typhi: Delay between Killing by Ceftazidime and Imipenem and Release of LPS
It has been suggested that the antibiotic-induced release of lipopolysaccharide (LPS) is an important cause
of the development of septic shock in patients treated for severe infections caused by gram-negative bacteria.
b-Lactam antibiotics change the integrity of the bacterial cell envelope by binding to penicillin-binding
proteins (PBP) in the membrane and thus may affect the amount of LPS that is released and the kinetics of
that release
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