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Antiplatelet Therapy in Ischemic Stroke and Transient Ischemic Attack An Over…
Stroke is a leading cause of mortality and disability worldwide. Initial manifestations of acute cerebral ischemia, such as ischemic stroke and transient ischemic attack (TIA), are often followed by recurrent vascular events, including recurrent stroke. To reduce this burden, antiplatelet therapy is a key component of the management of noncardioembolic ischemic stroke and TIA.
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Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in…
In patients with transient ischemic attack/ischemic stroke, microbleed burden predicts intracerebral hemorrhage (ICH), and ischemic stroke, but implications for antiplatelet treatment are uncertain. Previous cohort studies have had insufficient follow-up to assess the time course of risks, have not stratified risks by antithrombotic use, and have not reported extracranial bleeds or functional o…
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Oral antiplatelet therapy for acute ischaemic stroke (Review)
In people with acute ischaemic stroke, platelets become activated and can cause blood clots to form and block an artery in the brain, resulting in damage to part of the brain. Such damage gives rise to the symptoms of stroke. Antiplatelet therapy might reduce the volume of brain damaged by ischaemia and also reduce the risk of early recurrent ischaemic stroke, thereby reducing the risk of ear…
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Health-Related Quality of Life, Depressive Symptoms, and Kidney Transplant Ac…
Among individuals with chronic kidney disease (CKD), poor self-reported health is associated with adverse outcomes including hospitalization and death. We sought to examine the association between health-related quality-of-life (HRQoL) and depressive symptoms in advanced CKD and subsequent access to the kidney transplant waiting list.
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Global case studies for chronic kidney disease/end-stage kidney disease care
The prevalence of chronic kidney disease and its risk factors is increasing worldwide, and the rapid rise in global need for end-stage kidney disease care is a major challenge for health systems, particularly in low- and middle-income countries. Countries are responding to the challenge of end-stage kidney disease in different ways, with variable provision of the components of a kidney care str…
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Approach to the detection and management of chronic kidney disease What prima…
To help primary care providers, both family physicians and nurse practitioners, identify, detect, and manage patients with and at risk of chronic kidney disease (CKD), as well as outline criteria for appropriate referral to nephrology
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COVID-19 and diabetes mellitus: from pathophysiology to clinical management
Initial studies found increased severity of coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), in patients with diabetes mellitus. Furthermore, COVID-19 might also predispose infected individuals to hyperglycaemia. Interacting with other risk factors, hyperglycaemia might modulate immune and inflammatory responses, thus …
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Current best practice in the management of Turner syndrome
Turner syndrome (TS) is characterized by partial or complete loss of the second X-chromosome in phenotypic females resulting in a constellation of clinical findings that may include lymphedema, cardiac anomalies, short stature, primary ovarian failure and neurocognitive difficulties. Optimizing health care delivery is important to enable these individuals achieve their full potential. We revie…
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Long-Term Outcomes in Patients With Turner Syndrome: A 68-Year Follow-Up
Turner syndrome (TS) is the most common sex chromosome abnormality in women and is associated with increased morbidity and mortality. We describe long-term outcomes in a large cohort of patients with TS
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Turner syndrome: mechanisms and management
Turner syndrome is a rare condition in women that is associated with either complete or partial loss of one X chromosome, often in mosaic karyotypes. Turner syndrome is associated with short stature, delayed puberty , ovarian dysgenesis, hypergonadotropic hypogonadism, infertility , congenital malformations of the heart, endocrine disorders such as type 1 and type 2 diabetes mellitus, osteoporo…
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