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OXYGEN TOXICITY AFTER HYPERBARIC OXYGEN THERAPY
Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen intermittently in a chamber (either mono- or multiplace chamber) at a pressure greater than one atmosphere absolute (1 ATA). Osteomyelitis of the maxilla is very rare due to the high vasculature of this bone. Hyperbaric oxygen therapy is used in the treatment of refractory osteomyelitis A 24-year-old female received HBOT for treat…
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Paradigms of Oxygen Therapy in Critically Ill Patients
Oxygen administration to patients has potential advantages and some evident drawbacks. Several clinical settings, mainly critical scenarios, demand high oxygen inspired fractions (FiO2) in order to assure safe reserve margins for an eventual arterial desaturation (for example before tracheal intubation in operating room).
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Vaccine development and therapeutic design for 2019‐nCoV/SARS‐CoV‐2: Ch…
The ongoing outbreak of the recently emerged 2019 novel coronavirus (nCoV), which has seriously threatened global health security, is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with high morbidity and mortality. Despite the burden of the disease worldwide, still, no licensed vaccine or any specific drug against 2019‐nCoV is available
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Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine…
With the unprecedented morbidity and mortality associated with the COVID-19 pandemic, a vaccine against COVID-19 is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated vaccine candidate against COVID-19, containing inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for its safety, tolerability and immunogenicity
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Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Eval…
To evaluate the efficacy of two doses of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac in symptomatic individuals, with virological confirmation of COVID-19, two weeks after the completion of the two-dose vaccination regimen, aged 18 years or older who work as health professionals providing care to patients with possible or confirmed COVID-19. To describe the occurrence of adv…
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Early diagnosis of dengue disease severity in a resource-limited Asian country
Dengue is endemic throughout Cambodia, a country faced with significant health and economic challenges. We undertook a clinical study at the National Paediatric Hospital in Phnom Penh to evaluate clinical diagnostic parameters for dengue and predictors of disease outcome
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Diagnosis of dengue: an update
Early diagnosis of dengue, the most common mosquito-borne disease globally, remains challenging. Dengue presents initially as undifferentiated fever, with symptoms becoming more pathognomonic in the later stages of illness. This limits the timeliness in the delivery of appropriate supportive interventions. Laboratory tests are useful for diagnosis although the short-lived viremia and the presen…
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Early Diagnosis of Dengue Infection Using a Commercial Dengue Duo Rapid Test …
A commercial Dengue Duo rapid test kit was evaluated for early dengue diagnosis by detection of dengue virus NS1 antigen and immunoglobulin M (IgM)/IgG antibodies. A total of 420 patient serum samples were subjected to real-time reverse transcription-polymerase chain reaction (RT-PCR), in-house IgM capture enzyme-linked immunosorbent assay (ELISA), hemagglutination inhibition assay, and the SD …
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Vaccine development and therapeutic design for 2019‐nCoV/SARS‐CoV‐2: Ch…
The ongoing outbreak of the recently emerged 2019 novel coronavirus (nCoV), which has seriously threatened global health security, is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) with high morbidity and mortality. Despite the burden of the disease worldwide, still, no licensed vaccine or any specific drug against 2019‐nCoV is available. Data from several countri…
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ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-…
The SARS-CoV-2 causing COVID-19 has reached pandemic levels since March 2020. In the absence of vaccines or curative medical treatment, COVID-19 exerts an unprecedented global impact on public health and health care delivery. Owing to the unexpected need for large capacities of intensive care unit (ICU) beds with the ability to provide respiratory support and mechanical ventilation, temporary r…
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