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The Diagnosis and Management of Necrotising Fasciitis
The term necrotising fasciitis (NF) refers to severe inflammation of the muscle sheath that leads to necrosis ofrnthe subcutaneous tissue and adjacent fascia. It is associated with a significant risk of mortality and long-termr disability from limb and tissue loss. It occurs frequently enough that physicians outside critical care are likely torn be involved in the management of at least one pat…
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Autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and one of the most common causes of end-stage kidney disease. Multiple clinical manifestations, such as enlarged kidneys filled with growing cysts, hypertension, and multiple extrarenal complications, including liver cysts, intracranial aneurysms, and cardiac valvular disease, show that ADPKD i…
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Joint association of vitamins D and K status with long-term outcomes in stabl…
Kidney transplant recipients (KTRs) experience substantial survival benefit compared with dialysis patients. However, their mortality and graft failure risk remain high. KTRs are often low in micronutrient status, including vitamins D and K. We investigated the association of both vitamins D and K status, and vitamin D treatment with all-cause mortality and death-censored graft failure.
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CLINICAL VALUE OF SCREENING PERITONEAL DIALYSIS PATIENTS FOR BACTERIAL COLONI…
The adoption of the International Society for Peritoneal Dialysis guideline of using mupirocin ointment has been limited by fear of developing mupirocin-resistant organisms. We performed a surveillance program of a large peritoneal dialysis (PD) unit
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Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategies
Anorexia and reduced food intake are important issues in the management of patients with cancer because they contribute to the development of malnutrition, increase morbidity and mortality, and impinge on quality of life.
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Metabolic Encephalopathies
Kinnier Wilson coined the term metabolic encephalopathy to describe a clinical state of global cerebral dysfunction induced by systemic stress that can vary in clinical presentation from mild executive dysfunction to deep coma with decerebrate posturing; the causes are numerous. Some mechanisms by which cerebral dysfunction occurs in metabolic encephalopathies include focal or global cerebral e…
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Systematic review: portal vein thrombosis in cirrhosis
Portal vein thrombosis is encountered in 10–25% of cirrhotics. In terms of pathophysiology, cirrhosis is no longer considered a hypocoagulable state; rather than a bleeding risk in cirrhosis, various clinical studies support a thrombotic potential. Clinical findings of portal vein thrombosis in cirrhosis vary from asymptomatic disease to a life-threatening condition at first presentation
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Heart Failure in the diabetic patient – epidemiology, etiology, prognosis, …
In the type 2 diabetic patient the frequency of heart failure (HF) is increased and the mortality from HF is higher than with non-diabetic HF. The increased frequency of HF is due to the cardiotoxic tetrad of ischemic heart disease, left ventricular hypertrophy, diabetic cardiomyopathy and an extracellular volume expansion resistant to atrial natriuretic peptides
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Pharmacokinetics and Side-Effects of Clonidine
single oral dose of clonidine 309 ~tg was administered to 8 healthy, normotensive subjects and the time course of its plasma concentrations was followed for 24 h.
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Infections and risk-adjusted length of stay and hospital mortality in Polish …
The median LOS for neonates with infections was twice as high as for neonates without infection. LOS was significantly affected by the overall general condition of the neonate, as expressed by both gestational age and birth weight as well as by the Clinical Risk Index for Babies (CRIB) score; another independent factor was presence of at least one infection. Risk of in-hospital mortality was…
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