Tolerability of high-dose ceftriaxone in CNS infections: a prospective multic…

High-dose ceftriaxone for CNS infection administered as recommended by French guidelines in adults was well tolerated overall, suggesting these recommendations could be applied and generalized. In patients with advanced age or renal insufficiency, prescription should be done with caution and therapeutic drug monitoring could be useful.

Circulating Cytokines and Histological Liver Damage in Chronic Hepatitis B In…

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Evaluation of serum levels of IL-6, TNF-, IL-10,IL-2 and IL-4 in patients wit…

Changes in various cytokine activities have been reported during both HBV andHCV infections, while an imbalance of pro-inflammatory and anti-inflammatory cytokineproduction influences their immunopathogenesis. The aims of the present study are (a) tomeasure serum levels of interleukin-6 (IL-6), tumor necrosis factor  (TNF-), interleukin-10(IL-10), interleukin-2 (IL-2) and interleukin-4 (IL-4)…

Cytokine storm in Covid-19-Immunopathological mechanisms, clinical considerat…

Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness inmany conditions including viral infections, cancer, sepsis, andmulti-organ failure. The phenomenon has been implicated in critically ill patients infected with SARS-CoV-2, the novel coronavirus implicated in COVID-19. Critically ill COVID-19 patients experiencing cytokine storm are believed to …

Assessment of quality of life in patients with epilepsy

Patients with epilepsy have a higher risk regarding low quality of life. Objective: to determine the impact of different clinical and demographic factor upon the quality of life. Material and methods: the study group was comprised by 113 patients diagnosed with epilepsy, evaluated between 01.03.2008 and 31.03.2010 in Neurology Clinic from Cluj-Napoca

Papillary Reconstruction using Hyaluronic Acid: A Review

The aim of this review is to analyse the use of hyaluronic acid injection in the interdental space to reconstruct the papilla in animal models and humans.

Application of hyaluronic acid as carriers in drug delivery

Hyaluronic acid has good biocompatibility, biodegradability, and nonimmunogenicity. In addition, it has the ability to recognize specific receptors that are overexpressed on the surface of tumor cells, and cancer drugs can be targeted to the tumor cells to better kill them. Therefore, hyaluronic acid has attracted much attention as drug delivery vehicle. Herein, the application of hyaluronic a…

Current options for the prevention of postoperative intra-abdominal adhesions

Postoperative adhesions are the most common cause of morbidity after abdominal and pelvic surgery. The clinical manifestations of postoperative adhesions can manifest within a few weeks or even several years after the surgery. They result from peritoneal irritation caused by surgical trauma or intra-abdominal infection. Normal peritoneal healing relies on the balance between fibrin deposition a…

Keratinocyte Growth Factor Combined with a Sodium Hyaluronate Gel Inhibits Po…

Postoperative intra-abdominal adhesion is a very common complication after abdominal surgery. One clinical problem that remains to be solved is to identify an ideal strategy to prevent abdominal adhesions. Keratinocyte growth factor (KGF) has been proven to improve the proliferation of mesothelial cells, which may enhance fibrinolytic activity to suppress postoperative adhesions. This study in…

Meta‑analysis on the use of hyaluronic acid gel to prevent intrauterine adh…

Intrauterine adhesion (IUA) is a severe complication that occurs following abortion, and hyaluronic acid gel has been used to prevent IUA following intrauterine operation. The present study aimed to systematically evaluate the efficacy of hyaluronic acid gel in preventing IUA following intrauterine operation. In the current study, a literature search was performed using PubMed, Cochrane Librar…