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Chemotherapy-Induced Nausea and Vomiting: Pathogenesis, Recommendations, and…
The significant physical and emotional effects of chemotherapy-induced nausea and vomiting (CINV) are experienced by cancer patients. Severe symptoms decrease the patient’s quality of life and potentially deters further treatment. The five main forms of CINV (i.e., acute, delayed, anticipatory, breakthrough, and refractory) require different treatment regimens, which often include 5-HT3 recep…
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Flunarizine in the prophylaxis of migrainous vertigo: a randomized controlled…
Migrainous vertigo is a common cause of dizziness presenting to an otorhinolaryngology/otoneurology clinic. Although it causes a substantial burden to the individual and society there are no randomized controlled trails on prophylactic medication for this condition. Flunarizine, a calcium channel blocker has been used effectively in both migraine and vestibular conditions. This randomized c…
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Flunarizine versus betahistine in vertigo: a systematic review
We systematically searched electronic databases from the Cochrane Library, PubMed, Trip Database and Scopus. The other resource that we searched included web directory (google scholar). We also made hand searching. We included the previous randomized controlled trials (RCTs) regarding the efficacy of flunarizine comparing with betahistine. Our primary outcome was vegetative symptoms improvement…
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European Headache Federation (EHF) critical re-appraisal and meta-analysis of…
Novel disease‑specific and mechanism‑based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic anti‑migraine drugs. In this systematic review and meta‑analysis, we aimed to identify and rate the evidence for efficacy of flunarizine, a repurposed, first‑ or second‑line trea…
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Flunarizine: a review of its role in migraine prophylaxis
Flunarizine, a potent calcium channel blocker has been used for more than three decades for the prophylactic management of migraine. Theories suggest that flunarizine may act through multiple mechanisms such as inhibition of cortical spreading depression, neurogenic inflammation and channelopathy. Flunarizine is efficacious in the management of various types of migraines such as common, classic…
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Can flunarizine be used routinely as the first option for childhood headache …
The prevalence of headache in childhood increases due to environmental factors. Various risk factors in children whose playgrounds are restricted outside and therefore remain inactive. So diagnosis and treatment can be challenging. The aim of this study was to evaluate the experience of flunarizine in childhood headache with a focus on efficacy and success
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Prognostic value of dynamic electrocardiographic T wave changes in non-ST ele…
To assess the relationship between the evolution of T wave inversion (TWI) on the 24–48 h postadmission ECG and the patient characteristics, management and clinical outcomes among those with non-ST elevation acute coronary syndrome (NSTE-ACS).
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An update of genetic basis of PCOS pathogenesis
Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder that affects 5-20% of reproductive age women. PCOS clinical symptoms include hirsutism, menstrual dysfunction, infertility, obesity and metabolic syndrome. There is a wide heterogeneity in clinical manifestations and metabolic complications.
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Ultrasound for Cervical Length
The length of a cervix can be evaluated either by sonogram or physical examination of the cervix. Digital examination has been shown to be less consistent than ultrasound in the assessment of cervical length. The cervical length tends to be underestimated by manual examination by approximately 11 mm compared with ultrasound measurement
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Ultrasonography for Fetal Lung Masses
The differential diagnosis of congenital lung masses includes a variety of lesions, with congenital cystic adenomatoid malformation (CCAM) and bronchopulmonary sequestration (BPS) being the most commonly encountered
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