Alemtuzumab to Treat Refractory Autoimmune Hemolytic Anemia or Thrombocytopen…

Autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) are recognized complications of chronic lymphocytic leukemia (CLL) that can be life-threatening if not managed appropriately. Conventional therapies for these autoimmune disorders, such as corticosteroids, splenectomy, and immunosuppressive agents, may not induce complete resolution in all patients, and relapses are c…

Efficacy and safety of nebivolol in elderly heart failure patients with impai…

SENIORS recruited patients aged 70 years or older with symptomatic HF, irrespective of ejection fraction, and randomized them to nebivolol or placebo. Patients (n ¼ 2112) were divided by tertile of estimated glomerular filtration rate (eGFR). Mean age of patients was 76.1 years, 35% of patients had an ejection fraction of .35%, and 37% were women resulting in a unique cohort, far more represe…

Correlation between preoperative imaging features and intraoperative blood lo…

Correlation between preoperative imaging features and intraoperative blood loss meningioma: a new scoring system for predicting intraoperative blood loss

Pulmonary hypertension associated with left heart disease: Updated Recommenda…

In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH).

The Role of Vitamin D in Thyroid Diseases

The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin …

Vitamin D Deficiency Modulates Graves’ Hyperthyroidism Induced in BALB/c Mi…

TSH receptor (TSHR) antibodies and hyperthyroidism are induced by immunizing mice with adenovirus encoding the TSHR or its A-subunit. Depleting regulatory T cells (Treg) exacerbates thyrotoxicosis in susceptible BALB/c mice and induces hyperthyroidism in normally resistant C57BL/6 mice. VitaminDplays an important role in immunity; high dietary vitaminDintake suppresses (and low intake enhances)…

Differential diagnosis of ovarian cancer, benign ovarian tumor and endometriosis

We used a combination assay of serum sialyl SSEA-1 antigen (SLX) and CA125 levels, and evaluated the clinical usefulness of this technique for a differential diagnosis of ovarian cancer, benign ovarian tumor and endometriosis. In 82 patients with ovarian tumors, the sera of 20 (64.5%) of 31 with ovarian cancer and 15 (48.4%) of the 31 with endometriosis (endometrial cyst) were positive for both…

Clinical Diagnosis

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Haemophilia, state of the art and new therapeutic opportunities, a regulatory…

Haemophilia A and B are rare bleeding disorders. Over the past decades, they have been transformed from debilitating diseases to manageable conditions in the Western world. However, optimizing haemophilia care remains challenging in developing countries. Several challenges and unmet needs remain in the treatment of the haemophilia limiting the QoL of patients. These challenges are now being add…

Drugs to reduce bleeding and transfusion in adults undergoing cardiac surgery…

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy and safety of haemostatic drugs (including antifibrinolytics) and topical agents for reducing bleeding, transfusion, and reoperation in adults undergoing cardiac surgery