N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene cit…

To evaluate the effect of N-acetyl-cysteine (NAC), a mucolytic drug with insulin sensitizing properties, as an adjuvant therapy in subjects with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC).

Effect of Telmisartan on Atrial Fibrillation Recurrences in Patients with Hyp…

MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched. Random controlled trials (RCTs) were conducted in which telmisartan was compared to other antihypertensive drugs for AF recurrences prevention in hypertensive patients with paroxysmal AF. A systematic review and meta-analysis based on aggregate data extracted from the included studies were carried out to asse…

Systematic review of the effect of telmisartan on insulin sensitivity in hype…

Telmisartan is an angiotensin receptor blocker (ARB) originally developed for the treatment of hypertension. It can also partially activate peroxisome proliferator-activated receptor (PPAR)-, which may improve insulinsensitivity. This effect may prove useful in hypertensive patients with insulin resistance or diabetes mellitus. Such activity is more marked than that observed with other ARBs. Th…

Thiamphenicol Induced Bone Marrow Suppression as a Therapy of Myeloproferativ…

Sixteen patients, suffering from myeloproliferative diseases (9 polycythaemia vera, 7 primary thrombocythaemia) and 20 control subjects were treated for 14 days with 1 g of thiamphenicol per day. The effect of 40 treatment cycles was studied. The regimen resulted in lowering the haemoglobin values by 4.8070 in controls (p >_ 0.001) and patients (p >_ 0.01); the reticulocyte count dropped 43 °7…

New G-CSF agonists for neutropenia therapy

Granulocyte colony-stimulating factor (G-CSF; filgrastim) and its pegylated form (pegfilgrastim) are widely used to treat neutropenia associated with myelosuppressive chemotherapy and bone marrow transplantation, AIDS-associated or drug-induced neutropenia, and neutropenic diseases. G-CSF facilitates restoration of neutrophil counts, decreases incidence of infection/febrile neutropenia and redu…

The immunology of asthma

Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (TH2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the TH17 subset of helper T cells, and…

Comparison of the Efficacy of Tenofovir Versus Tenofovir plus Entecavir in th…

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Left Ventricular Hypertrophy by the Surface ECG

Left ventricular hypertrophy (LVH) is defined as an increase in left ventricular mass (LVM) associated with structural changes of myocardium. The increase in LVM and associated changes are associated with changes in depolarization and repolarization, manifested as a variety of altered QRS and T patterns. Increased QRS voltage has been considered to be a specific ECG finding in LVH, and ECG crit…

Acute coronary syndromes in women and men

Evidence of sex-related disparities in the care and outcomes of patients with acute coronary syndrome (ACS) emerged >30 years ago, and yet the mechanisms behind these sex-specific differences remain unclear. In this Review, we discuss the current literature on differences between women and men in the clinical presentation, pathophysiology, evaluation, management, and outcomes of ACS. Although …

Diagnosis of Hepatic Nodules in Patients at Risk for Q1 Hepatocellular Carcin…

Unequivocal diagnosis with avoidance of false- positive results is very relevant in patients with liver disease in whom an imaging technique detects a nodule that raises the potential emergence of hepatocellular carcinoma (HCC). Although biopsy confirmation is standard in most cancers, several studies have shown that reliable HCC diagnosis may be established by imaging techniques in patient…