Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly encountered disease entity following chemotherapy for cancer treatment. Although only duloxetine is recommended by the American Society of Clinical Oncology (ASCO) for the treatment of CIPN in 2014, the evidence of the clinical outcome for new pharmaceutic therapies and non-pharmaceutic treatments has not been clearly determined
Nitric oxide-cyclic guanosine monophosphate (NO-cGMP) deficiency has been associated with an increased risk for cardiovascular disease (CVD).1,2 The term NO-cGMP de- ficiency refers to conditions that lead to the impaired bioavailability and bioactivity of NO and/or cGMP and involves mechanisms including endothelial NO-synthase (eNOS) substrate deficiency and/or competition, eNOS defects and/…
There is conflicting evidence regarding the role of residual pulmonary obstruction (RPO) or persistent right ventricular dysfunction (RVD) after pulmonary embolism (PE) as a predictor of recurrent venous thromboembolism (VTE). The aim of this study was to assess whether RPO or persistent RVD after PE is associated with recurrent VTE
Nitric oxide (NO) is a remarkable gaseous molecule with multiple and important roles in different organisms, including fungi. However, the study of the biology of NO in fungi has been hindered by the lack of a complete knowledge on the different metabolic routes that allow a proper NO balance, and the regulation of these routes. Fungi have developed NO detoxification mechanisms to combat nitr…
Morbid obesity, defined as bodymass index (BMI) ‡40 kg/m2, affects approximately 8% of United States adults and is a recognized risk factor for chronic kidney disease (CKD). We present the first focused biopsy-based study exploring the range of kidney diseases in this population. Among 3263 native kidney biopsies interpreted at Columbia University in 2017, we identified 248 biopsies from morb…
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This practical guideline is based on the current scientific ESPEN guidelines on nutrition in cancer patients.
Older subjects are at increased risk of partial or complete loss of independence due to acute and/or chronic disease and often of concomitant protein caloric malnutrition. Nutritional care and support should be an indispensable part of their management. Enteral nutrition is always the first choice for nutrition support. However, when patients cannot meet their nutritional requirements adequate…
Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout thernlifespan. The condition presents several challenges including varied modes of clinical presentation, a range ofrntimepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses,rnand unsettled perspectives on therapeutics in different patient sett…