Treatment of Acne Vulgaris

THE MANAGEMENT OF ACNE VULgaris by nondermatologists is increasing.1In this article we attempt to answer the question: what treatments in acne vulgaris have proven efficacy and how are these treatments best administered and individualized to optimize results and minimize complications?Weconsidered the efficacy and safety of topical retinoids, topical antimicrobials, systemic antibiotics, hormon…

The Safety and Tolerability of Lumbrokinase DLBS1033 in Healthy Adult Subjects

This study was aimed to evaluate the safety and tolerability of Lumbrokinase DLBS1033 in healthy adult subjects

Adjunctive Treatment with Lumbrokinase in NSTEMI patient: Evaluation with Myo…

Rupture of an atherosclerotic plaque is the usual initiating event in an acute coronary syndrome (ACS), leading to subsequent thrombus formation. Persistent thrombotic occlusion results in acute myocardial infarction (MI). Current American Heart Association (AHA) and European Society of Cardiology (ESC) recommendation for non-ST-elevation of myocardial infarction (NSTEMI) use antiplatelet and …

DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic…

The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity

Safety and efficacy of desloratadine in chronic idiopathic urticaria in clini…

Post-marketing surveillance studies (PMSS) of medications are often mandated by authorities, provide crucial insights for health services and are useful to define the clinical profiles of therapies. Desloratadine, a non-sedating, second-generation H1-receptor antagonist, is an effective and well-tolerated treatment for chronic idiopathic urticaria (CIU).

A Pharmacokinetic Profile of Desloratadine in Healthy Adults, Including Elderly

To characterise the pharmacokinetic profile of desloratadine and its main metabolite, 3-hydroxy (3-OH) desloratadine, in a patient population representative of the population studied in the desloratadine clinical efficacy and safety studies, including the elderly

Decongestant activiy of desloratadine in controlled-allergen-exposure trials

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Pharmacokinetics of desloratadine in children between 2 and 11 years of age

Single doses of desloratadine syrup (1.25 and 2.5 mg) were well tolerated in children 2–5 and 6–11 years old. Desloratadine exposure in children appears to be similar to that observed in adults, in whom efficacy has been established.

The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherap…

Six randomised controlled studies (4 donepezil and 2 memantine) reported use within the licensed indication and had Neuropsychiatric Inventory (NPI) data suitable for meta-analysis. BPSD showed significant improvement with donepezil compared with placebo [weighted mean difference (WMD) in NPI –3.51, 95% confidence interval (CI) –5.75, –1.27], whereas this was not the case for memantine (W…

Donepezil for dementia due to Alzheimer’s disease (Review)

Alzheimer’s disease is the most common cause of dementia in older people. One approach to symptomatic treatment of Alzheimer’s disease is to enhance cholinergic neurotransmission in the brain by blocking the action of the enzyme responsible for the breakdown of the neurotransmitter acetylcholine. This can be done by a group of drugs known as cholinesterase inhibitors. Donepezil is a choline…