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Efektivitas DLBS1442 dalam Penanganan Nyeri Endometriosis dan/atau Adenomiosis
DLBS1442 merupakan fraksi bioaktif Phaleria macrocarpa yang memiliki efekmenurunkan ekspresi reseptor estrogen-β (RE-β) dan enzim siklo-oksigenase 2 (COX-2) serta meningkatkan ekspresi gen reseptor progesteron. Ketiga mekanisme tersebut diduga berperan dalam keluhan nyeri pada endometriosis dan atau adenomiosis.
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Betahistine for symptoms of vertigo (Review)
Vertigo is a symptom in which individuals experience a false sensation of movement. This type of dizziness is thought to originate in the inner ear labyrinth or its neural connections. It is a commonly experienced symptom and can cause significant problems with carrying out normal activities. Betahistine is a drug that may work by improving blood flow to the inner ear. This review examines whet…
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Real‑World Effectiveness of Once‑Weekly Glucagon‑Like Peptide‑1 Recep…
The efficacy of once-weekly (OW) glucagon-like peptide-1 receptor agonists (GLP-1RAs) has been estab- lished in several trials in people with type 2 diabetes mellitus (T2DM); however, real-world evidence on their effectiveness is limited. This study evaluated the effectiveness of OW GLP-1RA regarding glycemic and weight outcomes, and relative to DPP-4i in a comparator analysis.
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Efficacy and safety of betahistine treatment in patients with Meniere’s dis…
What is the long term efficacy of betahistine dihydrochloride on the incidence of vertigo attacks in patients with Meniere’s disease, compared with placebo?
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Domperidone a review of its pharmacodynamic activity, pharmacokinetics therap…
Domperidone is a dopamine antagonist that does not readily enter the central nervous system. Given parenterally or orally it increases gastric emptying of liquids and increases lower oesophageal sphincter pressure in healthy subjects. The antiemetic and pharmacodynamic profile of domperidone is similar to that of metoclopramide, although domperidone has a lower propensity to cause extrapyramida…
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P-Glycoprotein in the Blood-Brain Barrier of Mice Influences the Brain Penetr…
The mouse mdr1a (also called mdr3) P-GP is abundant in the blood-brain barrier, and its absence in mdr1a (-/-) mice leads to highly increased levels of the drugs ivermectin, vinblastine, digoxin, and cyclosporin A in the brain. We show here that the drugs loperamide, domperidone, and ondansetron are transported substrates for the mouse mdr1a P-GP and its human homologue MDR1. Phenytoin is a rel…
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A New Method of Characterizing the Buccal Dissolution of Drugs
Over the last several years there has been a great increase in interest for liquid and dissolve-in-the-mouth dosage forms. This interest is spurred by the promise of improved patient compliance compared to tables and capsules, that have to be swallowed whole
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Dissolution Testing of Orally Disintegrating Tablets
Orally disintegrating tablets (ODT) are solid dosage forms that disintegrate in the oral cavity leaving an easy-to-swallow residue.The disintegration times are generally less than one minute.For orally disintegrating tablets,taste-masking of bitter or objectional-tasting drug substances is critical.The taste-masking aspect plays a significant role in dissolution method development,specification…
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Fast-Melting Tablets: Developments and Technologies
The demand for fast-melting tablets (FMTs) has been growing during the last decade, particularly for children and the elderly who have difficulty swallowing tablets and capsules.
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Multicenter collaborative randomized parallel group comparative study of pita…
Japanese patients with total cholesterol (TC)≥220 mg/dL were randomized to receive pitavastatin 2mg (n = 126) or atorvastatin 10 mg (n = 125) for 12 weeks. The primary endpoint was percent change from baseline in non-HDL-C level after 12 weeks of treatment. Reduction of non-HDL-C by pitavastatin treatment (39.0%, P = 0.456 vs. atorvastatin) was non-inferior to that by atorvastatin (40.3%). B…
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