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Comparison of the post-antibiotic effect (PAE) induced by ceftizoxime, ceftri…
The exposure of bacteria to various groups of antimicrobials at different concentrations can produce damage to the bacteria that persists even after removal of the antimicrobial agent. The post antibiotic effect (PAE) of b-lactams on aerobic Gram-negative bacilli is relatively short (o1 h), however, little information is available regarding anaerobic Gram-negative bacilli. We studied the PAE…
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A Review of Doripenem for the Treatment of Serious Bacterial Infections
Doripenem is a carbapenem bactericidal agent that demonstrates in vitro activity against a wide variety of Gram-negative and Gram-positive pathogens. In vitro data show that doripenem combines the intrinsic activity of meropenem against Gram-negative pathogens with the intrinsic activity of imipenem against Gram-positive pathogens. The availability of doripenem is particularly welcome in the cu…
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Efficacy of doripenem in the treatment of Pseudomonas aeruginosa experimental…
In this model of P. aeruginosa pneumonia, doripenem had an efficacy equivalent to that of meropenem and imipenem at a high dose of 1 g three times a day and lower efficacy at a standard dose (0.5 g three times daily) than the other two agents in terms of bacteria cultivated from spleens. Doripenem is a new drug that offers new therapeutic options, especially for difficult-to-treat infections su…
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Doripenem: A Review of its Use in the Treatment of Bacterial Infections
Doripenem, a parenteral, broad-spectrum antibacterial agent of the carbapenem family, is indicated as empirical therapy in serious bacterial infections in adults. Doripenem is indicated in Japan for use as a single agent in intra-abdominal infections (IAIs), lower respiratory tract infections (including nosocomial pneumonia), complicated urinary tract infections (cUTIs) and a variety of other b…
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THE STUDY ON THERAPEUTIC EFFICACY OF INOSINE PRANOBEX IN CHILDREN
Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The objective of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on the immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. Inosine pranobex (50 mg/kg b.w./day) in divide…
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Inosine pranobex is safe and effective for the treatment of subjects with con…
Inosine pranobex (Isoprinosine®) is an immunomodulatory drug approved in several countries for the treatment of viral infections. This study compared the efficacy and safety of inosine pranobex versus placebo in subjects with clinically diagnosed influenza-like illness, including subjects with laboratory-confirmed acute respiratory viral infections. Subgroup analyses evaluated the efficacy of …
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Multicenter randomized study of inosine pranobex versus acyclovir in the trea…
The objective of the study is to evaluate the efficacy and safety of oral inosine pranobex as compared with acyclovir in the treatment of recurrent herpes labialis (RHL) and recurrent herpes genitalis (RHG). A multicenter double-blind, double-dummy, randomized, controlled, parallel group trial was conducted in 144 patients with RHL and 144 RHG. Patients were assigned to treatment in one of two …
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Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.)Boerl…
Phaleria macrocarpa, commonly known as Mahkota dewa is a medicinal plant that is indigenous to Indonesia and Malaysia. Extracts of P. macrocarpa have been used since years in traditional medicine that are evaluated scientifically as well. The extracts are reported for a number of valuable medicinal properties such as anti-cancer, anti-diabetic, anti-hyperlipidemic, anti-inflammatory, anti-bacte…
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Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea wi…
DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflmmatory properties. The current clinical study evaluated the effiacy and safety of DLBS1442 in alleviating symptoms of premenstrual syndrome and primary dysmenorrhea
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Antioxidants, Phytochemicals, and Cytotoxicity Studies on P h a l e r i a m a…
In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased. Phaleria macrocarpa (Scheff) Boerl is frequently used in traditional medicine. Th present investigation was undertaken with the purpose of developing pharmacopoeial standards for this species. Nutritional values such as ash, fier, protein, fat, and carbohydrate contents were investig…
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