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Coronary Stent Restenosis in Patients Treated With Cilostazol
Restenosis after implantation of coronary artery stents remains a significant clinical problem. We undertook a randomized, double-blind, placebo-controlled trial to determine whether cilostazol, a drug that suppresses intimal proliferation, would reduce renarrowing in patients after stent implantation in native coronary arteries
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Astaxanthin decreased oxidative stress and inflammation and enhanced immune r…
Astaxanthin modulates immune response, inhibits cancer cell growth, reduces bacterial load and gastric inflammation, and protects against UVA-induced oxidative stress in in vitro and rodent models. Similar clinical studies in humans are unavailable. Our objective is to study the action of dietary astaxanthin in modulating immune response, oxidative status and inflammation in young healthy adult…
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Astaxanthin in Cardiovascular Health and Disease
Oxidative stress and inflammation are established processes contributing to cardiovascular disease caused by atherosclerosis. However, antioxidant therapies tested in cardiovascular disease such as vitamin E, C and β-carotene have proved unsuccessful at reducing cardiovascular events and mortality. Although these outcomes may reflect limitations in trial design, new, more potent antioxidant th…
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Antioxidant effect of astaxanthin on phospholipid peroxidation in human eryth…
Phospholipid hydroperoxides (PLOOH) accumulate abnormally in the erythrocytes of dementia patients, and dietary xanthophylls (polar carotenoids such as astaxanthin) are hypothesised to prevent the accumulation. In the present study, we conducted a randomised, double-blind, placebo-controlled human trial to assess the efficacy of 12-week astaxanthin supplementation (6 or 12 mg/d) on both astaxan…
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Investigation of prion removal/inactivation from chromatographic gel
Concerns about the potential for prions to be retained on chromatography gels during the manufacture of plasma products prompted development of an investigational strategy for detecting infectious prions bound to gels. The objective was to firstly examine methods of implanting gels intracerebrally (IC) in mice, then to examine prion cleaning from a scaled-down version of the DEAE Sepharose colu…
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Prion-removal capacity of chromatographic and ethanol precipitation steps use…
Although there is no epidemiological evidence to suggest that classical Creutzfeldt–Jakob disease (CJD) is transmitted through blood or blood products, the variant form (vCJD) has been implicated in transmission via packed red blood cells. The potential threat of the infectious agent contaminating plasma pools has led to manufacturing processes being examined for capacity to remove prions. Th…
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Peran Albumin dalam Penatalaksanaan Sirosis Hati
Infus albumin telah dipakai sejak puluhan tahun yang lalu sebagai salah satu pilihan terapi dalam praktek medis. Tujuannya adalah mengatasi kondisi hipoalbuminemia pada berbagai penyakit. Menurunnya kadar albumin dapat menjadi penyebab terjadinya kelainan tetapi lebih banyak merupakan komplikasi penyakit yang diderita sebelumnya. Banyaknya data yang membuktikan bahwa kadar albumin darah berka…
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Prevalence of Urinary tract infections in children and their sensitivity to v…
Urinary tract infection (UTI) is one of the most common infections of childhood and its prevalence varies markedly with sex and age. In this study, urinary specimens from 200 children under 14 years of age suffering from urinary tract infections were investigated for bacterial agents. The most common bacterial agents of urinary tract infections were Escherichia coli (71.7% of total isolates in …
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Practice Guidelines for the Diagnosis and Management of Skin and Soft-Tissue …
Soft-tissue infections are common, generally of mild to modest severity, and are easily treated with a variety of agents. An etiologic diagnosis of simple cellulitis is frequently difficult and generally unnecessary for patients with mild signs and symptoms of illness. Clinical assessment of the severity of infection is crucial, and several classification schemes and algorithms have been propo…
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In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary …
A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxi…
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