DLBS1033, A Protein Extract from Lumbricus rubellus, Possesses Antithrombotic…

The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity

Safety and efficacy of desloratadine in chronic idiopathic urticaria in clini…

Post-marketing surveillance studies (PMSS) of medications are often mandated by authorities, provide crucial insights for health services and are useful to define the clinical profiles of therapies. Desloratadine, a non-sedating, second-generation H1-receptor antagonist, is an effective and well-tolerated treatment for chronic idiopathic urticaria (CIU).

A Pharmacokinetic Profile of Desloratadine in Healthy Adults, Including Elderly

To characterise the pharmacokinetic profile of desloratadine and its main metabolite, 3-hydroxy (3-OH) desloratadine, in a patient population representative of the population studied in the desloratadine clinical efficacy and safety studies, including the elderly

Decongestant activiy of desloratadine in controlled-allergen-exposure trials

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Pharmacokinetics of desloratadine in children between 2 and 11 years of age

Single doses of desloratadine syrup (1.25 and 2.5 mg) were well tolerated in children 2–5 and 6–11 years old. Desloratadine exposure in children appears to be similar to that observed in adults, in whom efficacy has been established.

The Efficacy of Licensed-Indication Use of Donepezil and Memantine Monotherap…

Six randomised controlled studies (4 donepezil and 2 memantine) reported use within the licensed indication and had Neuropsychiatric Inventory (NPI) data suitable for meta-analysis. BPSD showed significant improvement with donepezil compared with placebo [weighted mean difference (WMD) in NPI –3.51, 95% confidence interval (CI) –5.75, –1.27], whereas this was not the case for memantine (W…

Donepezil for dementia due to Alzheimer’s disease (Review)

Alzheimer’s disease is the most common cause of dementia in older people. One approach to symptomatic treatment of Alzheimer’s disease is to enhance cholinergic neurotransmission in the brain by blocking the action of the enzyme responsible for the breakdown of the neurotransmitter acetylcholine. This can be done by a group of drugs known as cholinesterase inhibitors. Donepezil is a choline…

Beyond symptomatic effects: potential of donepezil as a neuroprotective agent…

Alzheimer’s disease (AD) is associated with neurodegenerative changes resulting clinically in progressive cognitive and functional deficits. The only therapies are the cholinesterase inhibitors donepezil, galantamine and rivastigmine and the N-methyl-Daspartate-receptor antagonist memantine. Donepezil acts primarily on the cholinergic system as a symptomatic treatment, but it also has potenti…

Clinical efficacy and safety of donepezil in the treatment of Alzheimer’s d…

Donepezil, an acetylcholinesterase inhibitor (AChEI), has been widely used to treat Alzheimer’s disease (AD) in China. However, there are few studies focusing on the efficacy and safety of donepezil in Chinese patients. In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factor…

Attention Measures of Accuracy, Variability, and Fatigue Detect Early Respons…

Donepezil is widely used to treat Alzheimer’s disease (AD), but detecting early response remains challenging for clinicians. Acetylcholine is known to directly modulate attention, particularly under high cognitive conditions, but no studies to date test whether measures of attention under high load can detect early effects of donepezil. We hypothesized that load-dependent attention tasks are …