Domperidone (D), a dopamine 2 receptor antagonist, is an effective anti-emetic that acts at the chemoreceptor trigger zone and only minimally crosses the blood brain barrier while also exerting prokinetic effects on the stomach and proximal small bowel. D is not approved in the USA. Recommended dosing worldwide is 30 mg/day and due to scattered reports of cardio toxicity ECG monitoring is reco…
To describe the health-related quality of life (HRQOL) of patients with insulin - t reated diabetes and symptoms of diabetic gastro p a resis and to assess the impact of domperidone on HRQOL in these patients
Allergy affects more than 15% of the world population, and some studies have shown that up 30% of the US population has some form of allergy. Most of these patients have various target organs for their allergies, and most have ocular involvement.
To compare the efficacy of etoricoxib 30 mg with the generally maximum recommended dose of celecoxib, 200 mg, in the treatment of steoarthritis (OA) in two identically designed studies
This randomized double-blind study compared the analgesic efficacy and tolerability of etoricoxib versus ketoprofen in 165 patients with elective total primary knee arthroplasty
Adapalene (Differin) is a retinoid agent indicated for the topical treatment of acne vulgaris. In clinical trials, 0.1% adapalene gel has proved to be effective in this indication and was as effective as 0.025% tretinoin gel, 0.1% tretinoin microsphere gel, 0.05% tretinoin cream and 0.1% tazarotene gel once every two days; however, the drug was less effective than once-daily 0.1% tazarotene …
Adapalene gel 0.3% was significantly superior to adapalene gel 0.1% and vehicle in success rate, total lesion count, and inflammatory lesion count. A consistent, dose-dependent effect was demonstrated for all efficacy measures. Signs and symptoms were mostly mild to moderate and transient in nature.
THE MANAGEMENT OF ACNE VULgaris by nondermatologists is increasing.1In this article we attempt to answer the question: what treatments in acne vulgaris have proven efficacy and how are these treatments best administered and individualized to optimize results and minimize complications?Weconsidered the efficacy and safety of topical retinoids, topical antimicrobials, systemic antibiotics, hormon…
This study was aimed to evaluate the safety and tolerability of Lumbrokinase DLBS1033 in healthy adult subjects
Rupture of an atherosclerotic plaque is the usual initiating event in an acute coronary syndrome (ACS), leading to subsequent thrombus formation. Persistent thrombotic occlusion results in acute myocardial infarction (MI). Current American Heart Association (AHA) and European Society of Cardiology (ESC) recommendation for non-ST-elevation of myocardial infarction (NSTEMI) use antiplatelet and …