Docetaxel: An Update of its Use in Advanced Breast Cancer

Docetaxel, a semisynthetic member of the taxoid class of antineoplastic agents, is effective in the treatment of patients with advanced (locally advanced or metastatic) breast cancer. Reported objective response rates for docetaxel 100 mg/m2 ranged from 54 to 69% and 53 to 82% as first-line monotherapy or combination therapy, respectively. Objective response rates of 23 to 65% and 30 to 81% ha…

Docetaxel

Multicenter and single-institution studies have demonstrated docetaxel's consistent significant activity in various cancers. Phase III and combination therapy trials are ongoing. Work is in progress to understand and prevent/resolve some of this drug's side effects

Vaginitis

SYMPTOMS of vaginitis are nonspecific, and neither self-diagnosis nor diagnosis by a physician is reliable without laboratory confirmation. The management of vaginitis remains largely empirical, and many assume that vaginitis is never life-threatening and that empirical therapy is always harmless. Vulvovaginitis, although frequently the result of infection, may also have noninfectious causes (T…

Metronidazole-induced encephalopathy and inferior olivary hypertrophy

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Diagnosis and Treatment of Infectious Vaginitis

Infectious vaginitis, which includes the three vaginal infections trichomoniasis, bacterial vaginosis, and candidiasis, is a common disorder in women.1 Diagnosis of infectious vaginitis is particularly important in pregnant women. Pregnant women diagnosed with bacterial vaginosis, such as the patient reviewed in this case study, have an elevated risk of preterm labor, preterm rupture of membran…

Lipoic Acid Reduces the Activities of Biotin-Dependent Carboxylases in Rat Liver

In the past, lipoic acid has been administered to patients and test animals as therapy for diabetic neuropathy and various intoxications. Lipoic acid and the vitamin biotin have structural similarities. We sought to determine whether the chronic administration of lipoic acid affects the activities of biotin-dependent carboxylases. For 28 d, rats received daily intraperitoneal injections of one …

Chromium, Glucose Intolerance and Diabetes

Within the last 5 years chromium (Cr) has been shown to play a role in glucose intolerance, Type 2 diabetes mellitus (Type 2 DM), and gestational diabetes. In addition, diabetes and the neuropathy of a patient on home parenteral nutrition were alleviated when supplemental Cr was added to total parenteral nutrition (TPN) solutions. In a study conducted in China that has been supported by studies…

Effects of ramipril on cardiovascular and microvascular outcomes in people wi…

Diabetes mellitus is a strong risk factor for cardiovascular and renal disease. We investigated whether the angiotensin-converting-enzyme (ACE) inhibitor ramipril can lower these risks in patients with diabetes

Use of ramipril in preventing stroke: double blind randomised trial

To determine the effect of the angiotensin converting enzyme inhibitor ramipril on the secondary prevention of stroke.

Ramipril and the Development of Diabetes

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