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High-dose antithrombin III in the treatment of severe sepsis in patients with…
To explore if patients with severe sepsis and with a predicted high risk of death (according to the Simplified Acute Physiology Score II) might have a treatment benefit from highdose antithrombin III.
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Dobutamine (hydrochloride)
Dobutamine is a synthetic catecholamine used in the treatment of shock and in cardiac stress testing. It is a chiral molecule and both (+) and (-) isomers are pharmacolgically active but there are important differences in their adrenergic receptor subtype selectively
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Ephedrine, dopamine, or dobutamine to treat hypotension with propofol during …
To compare the efficacy of ephedrine, dopamine and dobutamine for circulatory support during thoracic epidural anesthesia after anesthetic induction with propofol.
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Dopexamine, Dobutamine, and Dopamine Increase Splanchnic Blood Flow : What Is…
Inadequate splanchnic perfusion in the critically ill compromises the gut barrier leading to bacterial translocation, which is postulated to cause multiorgan dysfunction and failure. Inotropic agents such as dopexamine, dobutamine, and dopamine may have a role in increasing splanchnic perfusion, thereby protecting this area from further injury
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Comparison of the haemodynamic effects of dopamine and dobutamine in young ch…
Nineteen children, aged 2-54 months, requiring high-dose inotropic support after cardiac surgery, were given either dopamine or dobutamine in a blinded, double crossover, study. Using a pulmonary artery thermistor, right and left atrial cannulae, and pulmonary and femoral arterial catheters, conventional haemodynamic variables were measured hourly over three consecutive 4 h dopamine-dobutamine-…
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Dobutamine Hydrochloride
Dobutamine hydrochloride is available in 20-, 40-, and 100-mL single-dose vials as a concentrate for injection. Each mL contains 12.5 mg of dobutamine (as the hydrochloride), sodium bisulfite 0.24 mg, and hydrochloric acid and/or sodium hydroxide to adjust the pH. Dobutamine hydrochloride concentrate for injection must be diluted further to a concentration not greater than 5 mg/mL before ad…
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Docetaxel: A Review of its Use for the First-Line Treatment of Advanced Cast…
Docetaxel (Taxotere) is a well established anti-mitotic chemotherapy agent. Among other therapeutic indications, docetaxel plus prednisone is indicated for first-line chemotherapy in patients with castration-resistant prostate cancer (CRPC)
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Phase I Trial of Docetaxel Administered by Weekly Infusion in Patients With A…
Docetaxel is a highly active antineoplastic agent; however, grade IV leukopenia occurs in the large majority of patients treated with a dose of 100 mg/m2 every 3 weeks. Recent experience with weekly paclitaxel has demonstrated a bone marrow-sparing effect when a weekly administration schedule is used. We investigated a weekly schedule of docetaxel in an attempt to alter the toxicity profile a…
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Efficacy of Docetaxel 60 mg/m2 in Patients With Metastatic Breast Cancer Acco…
To evaluate the efficacy of docetaxel 60 mg/m2 in metastatic breast cancer (MBC) according to the status of anthracycline resistance
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Taxanes for the Treatment of Metastatic Breast Cancer
Taxanes have remained a cornerstone of breast cancer treatment over the past three decades, improving the lives of patients with both early- and late-stage disease. The purpose of this review is to summarize the current role of taxanes, including an albuminbound formulation that enhances delivery of paclitaxel to tumors, in the management of metastatic breast cancer (MBC). Since the introduct…
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