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Contribution of midazolam and its 1-hydroxy metabolite to preoperative sedati…
Oral midazolam is widely used for preoperative sedation in children. We have studied the pharmacokinetics (PK) of both midazolam and its active l-hydroxy metabolite and their contributions to sedative effect in 45 children attending for day surgery.
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Midazolam (Systemic)
Adjust dosage according to individual requirements and response, age, body weight, physical and clinical status, underlying pathologic condition(s), type and amount of premedication or concomitant medication, and the nature and duration of the surgical or other procedure; however, individual response also may vary independent of these factors.
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Midazolam Premedication in Children : Comparison of Nasal and Sublingual Routes
In a prospective randomized study efficacy of nasal and sublingual administration of midazolam as premedication in children was evaluated in 60 children aged between 4-10 years with ASA physical status I and II. Patients were divided into two groups of 30 patients each and received midazolam 0.2mgkg-1 either intranasally or sublingually in a randomized manner. Heart rate, oxygen saturation, res…
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Intravenous midazolam infusion for sedation of infants in the neonatal intens…
Proper sedation for neonates undergoing uncomfortable procedures may reduce stress and avoid complications. Midazolam is a shortacting benzodiazepine that is increasingly used in neonatal intensive care units (NICU). However, its effectiveness as a sedative in neonates has not been systematically evaluated
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Sedation Guidelines for Midazolam Infusion during Combined Spinal and Epidura…
To investigate the adequate infusion dose regimen of midazolam to induce sedation with the Ramsay score 4 with rapid onset during combined spinal and epidural anesthesia
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Anesthetic Choice of Halothane Versus Propofol: Impact on Experimental Periop…
It is not known whether preischemic exposure to anesthetic agents affects the amount of damage from transient focal ischemia that occurs after cessation of the anesthetic. We compared the effect of prior exposure to halothane or propofol on infarction size after transient middle cerebral artery occlusion (MCAO) induced in the awakening animal to test the hypothesis that anesthetic type and expo…
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RAPID INDUCTION OF HALOTHANE ANAESTHESIA IN MAN
The inhalation induction of general anaesthesia is usually avoided by both patients and anaesthetists, since a prolonged induction may terrify both adults and children. In addition, the anaesthetist may have difficulty maintaining the airway and restraining the muscular patient if excitement occurs. Intravenous induction is popular because these complications are usually avoided
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DISSEMINATED INTRAVASCULAR COAGULATION
DISSEMINATED intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels
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Coagulation in sepsis: all bugs bite equally
Sepsis almost invariably leads to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation. There is compelling evidence from clinical and experimental studies that disseminated intravascular coagulation is involved in the pathogenesis of microvascular dysfunction and contributes to organ failure. Data from the PROWESS phase III c…
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Antithrombin III in critically ill patients: systematic review with meta-anal…
To evaluate the benefits and harms of antithrombin III in critically ill patients
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