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Antioxidant effect of astaxanthin on phospholipid peroxidation in human eryth…
Phospholipid hydroperoxides (PLOOH) accumulate abnormally in the erythrocytes of dementia patients, and dietary xanthophylls (polar carotenoids such as astaxanthin) are hypothesised to prevent the accumulation. In the present study, we conducted a randomised, double-blind, placebo-controlled human trial to assess the efficacy of 12-week astaxanthin supplementation (6 or 12 mg/d) on both astaxan…
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Investigation of prion removal/inactivation from chromatographic gel
Concerns about the potential for prions to be retained on chromatography gels during the manufacture of plasma products prompted development of an investigational strategy for detecting infectious prions bound to gels. The objective was to firstly examine methods of implanting gels intracerebrally (IC) in mice, then to examine prion cleaning from a scaled-down version of the DEAE Sepharose colu…
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Prion-removal capacity of chromatographic and ethanol precipitation steps use…
Although there is no epidemiological evidence to suggest that classical Creutzfeldt–Jakob disease (CJD) is transmitted through blood or blood products, the variant form (vCJD) has been implicated in transmission via packed red blood cells. The potential threat of the infectious agent contaminating plasma pools has led to manufacturing processes being examined for capacity to remove prions. Th…
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Peran Albumin dalam Penatalaksanaan Sirosis Hati
Infus albumin telah dipakai sejak puluhan tahun yang lalu sebagai salah satu pilihan terapi dalam praktek medis. Tujuannya adalah mengatasi kondisi hipoalbuminemia pada berbagai penyakit. Menurunnya kadar albumin dapat menjadi penyebab terjadinya kelainan tetapi lebih banyak merupakan komplikasi penyakit yang diderita sebelumnya. Banyaknya data yang membuktikan bahwa kadar albumin darah berka…
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Prevalence of Urinary tract infections in children and their sensitivity to v…
Urinary tract infection (UTI) is one of the most common infections of childhood and its prevalence varies markedly with sex and age. In this study, urinary specimens from 200 children under 14 years of age suffering from urinary tract infections were investigated for bacterial agents. The most common bacterial agents of urinary tract infections were Escherichia coli (71.7% of total isolates in …
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Practice Guidelines for the Diagnosis and Management of Skin and Soft-Tissue …
Soft-tissue infections are common, generally of mild to modest severity, and are easily treated with a variety of agents. An etiologic diagnosis of simple cellulitis is frequently difficult and generally unnecessary for patients with mild signs and symptoms of illness. Clinical assessment of the severity of infection is crucial, and several classification schemes and algorithms have been propo…
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In-vitro susceptibility of 1982 respiratory tract pathogens and 1921 urinary …
A total of 3903 pathogens from 48 Canadian medical centres were tested against 19 antimicrobial agents. Five agents showed activity against 90% of all 1982 respiratory tract pathogens tested (ciprofloxacin, 90%; cefoperazone, 91%; ticarcillin/clavulanate, 92%; ceftazidime and imipenem, 93% each). Nine agents had 90% activity against Enterobacteriaceae from respiratory tract infection (cefotaxi…
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Comparison of the post-antibiotic effect (PAE) induced by ceftizoxime, ceftri…
The exposure of bacteria to various groups of antimicrobials at different concentrations can produce damage to the bacteria that persists even after removal of the antimicrobial agent. The post antibiotic effect (PAE) of b-lactams on aerobic Gram-negative bacilli is relatively short (o1 h), however, little information is available regarding anaerobic Gram-negative bacilli. We studied the PAE…
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A Review of Doripenem for the Treatment of Serious Bacterial Infections
Doripenem is a carbapenem bactericidal agent that demonstrates in vitro activity against a wide variety of Gram-negative and Gram-positive pathogens. In vitro data show that doripenem combines the intrinsic activity of meropenem against Gram-negative pathogens with the intrinsic activity of imipenem against Gram-positive pathogens. The availability of doripenem is particularly welcome in the cu…
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Efficacy of doripenem in the treatment of Pseudomonas aeruginosa experimental…
In this model of P. aeruginosa pneumonia, doripenem had an efficacy equivalent to that of meropenem and imipenem at a high dose of 1 g three times a day and lower efficacy at a standard dose (0.5 g three times daily) than the other two agents in terms of bacteria cultivated from spleens. Doripenem is a new drug that offers new therapeutic options, especially for difficult-to-treat infections su…
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