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Mechanism of action of lenalidomide in hematological malignancies
Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide is a 4-amino-glutamyl analogue of thalidomide that lacks the neurologic side effects of sedation and neuropathy and has emerged as a drug with activity against various hematological and solid mali…
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Striatin-Dependent Membrane Estrogen Receptor Signaling and Vasoprotection by…
Estrogen activates multiple signaling pathways in most target cells and tissues, including those within the cardiovascular system. Functional ERs, ER and ER, are expressed on cardiomyocytes in the heart and by endothelial and smooth muscle cells within blood vessels. Early studies indicated that ERs are ligand-activated transcription factors, which exist primarily in the nucleus complexed wi…
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Aldosterone’s Rapid, Nongenomic Effects Are Mediated by Striatin: A Modulat…
The cellular responses to steroids are mediated by 2 general mechanisms: genomic and rapid/ nongenomic effects. Identification of the mechanisms underlying aldosterone (ALDO)’s rapid vs their genomic actions is difficult to study, and these mechanisms are not clearly understood. Recent data suggest that striatin is a mediator of nongenomic effects of estrogen. We explored the hypothesis that …
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Inositol – Clinical Applications for Exogenous Use
Recent advances in nutritional and biochemical research have documented inositol as an important dietary and cellular constituent. The processes involved in inositol metabolism and its derivatives in the tissues of mammals have been characterized in vivo as well as at the enzymatic level. Biochemical functions defined for phosphatidylinositol in biological membranes include the regulation of ce…
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Potential effect of striatin (DLBS0333), a bioactive protein fraction isolate…
Striatin contained four major bioactive proteins with approximate molecular weight of 8.3, 10.9, 15.4 and 16.7 kDa. In addition to proteins, striatin also contained amino acids (10 essential and 7 non essential amino acids), fatty acids (palmitic acid, oleic acid, stearic acid, linoleic acid, arachidonic acid), vitamins (vitamin A, vitamin B6) and other nutrients (carbohydrate, dietary fiber, b…
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Channa striatus capsules induces cytokine conversion in pulmonary tuberculosi…
The rate of positive sputum smear decline was more pronounced in the Channa striatus group but did not reach statistically different value between groups. The levels of TNF-α, IFN-γ, and IL-10 were not significantly different in Channa striatus group compared to placebo group at baseline (week 0). But at week 12, the supplementation of Channa striatus capsule significantly decreased TNF-α, I…
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Efficacy and safety of domperidone and metoclopramide on human milk productio…
Breastfeeding is the most advantageous nutrition for infants because of its many health benefits. However, lactation insufficiency is a prevalent issue among women, particularly those who give birth prematurely. Galactagogues, such as domperidone and metoclopramide, have been reported and may be beneficial for lactation insufficiency. However, the optimal pharmacological galactagogue remains un…
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AGA Clinical Practice Guideline on Management of Gastroparesis
BACKGROUND & AIMS: Gastroparesis is a complex gastric motility disorder characterized by nausea, vomiting, and other symptoms associated with a delay in gastric emptying in the absence of mechanical obstruction. Variations in diagnostic testing and limited effective treatments make caring for this patient population challenging. The American Gastroenterological Association developed this guidel…
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Is there a link between plasma progesterone 1–2 days before frozen embryo t…
Objective: To study the efficacy of a new P preparation in aqueous solution for subcutaneous injection for inducing the predecidual transformation of the endometrium.
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A randomized trial comparing the endometrial effects of daily subcutaneous ad…
Objective: To study the efficacy of a new P preparation in aqueous solution for subcutaneous injection for inducing the predecidual transformation of the endometrium
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