The therapeutic efficacy of erdosteine in the treatment of chronic obstructiv…

Erdosteine, a drug approved for the treatment of acute and chronic pulmonary diseases, has been shownrnto be an effective treatment for chronic bronchitis or COPD (CB/COPD) in several studies, althoughrnmarked differences in the perception of its usefulness still remain.

Erdosteine in children and adults with bronchiectasis (BETTER trial): study p…

Bronchiectasis is a worldwide chronic lung disorder where exacerbations are common. It affects people of all ages, but especially Indigenous populations in high-income nations. Despite being a major contributor to chronic lung disease, there are no licensed therapies for bronchiectasis and there remain relatively few randomised controlled trials (RCTs) conducted in children and adults. Our RCT…

Decreased Mortality With Beta-Blockers in Patients With Heart Failure and Coe…

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Optimal Use of Beta-Blockers for Congestive Heart Failure

Beta-blockers are the cornerstone treatment for congestive heart failure (HF). Current HF guidelines commonly recommend β-blockers for the treatment of HF with reduced left ventricular ejection fraction (LVEF). The effect of β-blockers, however, is less clear for HF patients with preserved LVEF, unstable severe acute HF, or right ventricular failure. This review summarizes the effect of β-b…

Duplex Scanning of the Peripheral Arteries: Correlation of the Peak Velocity …

The correlation of the peak systolic velocity (PSV) and the peak velocity ratio (PVR, calculated as intrastenotic PSV divided by proximally recorded PSV) with percent diameter reduction was studied in 62 patients with peripheral arterial occlusive disease. PSV values correlated well with angiographic diameter reduction (r =0.81, n = 106 stenoses), but due to large variability the sensitivity an…

A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal M…

Limited data exist on the effects of extracorporeal membrane oxygenation on pharmacokinetics of cefepime in critically ill pediatric patients. The objective was to describe cefepime disposition in children treated with extracorporeal membrane oxygenation using population pharmacokinetic modeling.

Multifaceted Beneficial Effects of Erdosteine: More than a Mucolytic Agent