Changes in Immunological Parameters by Standardized Phyllanthus niruri Extrac…

One of traditional herbs used as medicine in many countries for various uses is the herb Phyllanthus niruri L. Many pre-clinical studies have explored its activities on the immune system. Further pre-clinical studies were done to determine its safety and immunomodulating characteristics on mice and rats. The results of these studies suggested that Phyllanthus niruri L extract is able to modulat…

Pengobatan Oral Infeksi Virus Varicella-zoster dengan Kombinasi Ekstrak Phyll…

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Perbandingan Kesembuhan Penderita Kandidiasis Vagina Yang Mendapat Pengobatan…

Rancangan penelitian adalah eksperimental dengan uji klinik perlakuan. Sampel diambil secara acak sederhana dan buta ganda. Jumlah penderita yang didapat mulai Februari hingga Juni 2004 di Yayasan Kanker Wisnuwardhana Surabaya sebanyak 30 orang yang dibagi menjadi 2 kelompok, masing-masing 15 penderita. Kelompok A mendapatkan Ketokonazol 2x200 mg selama 5 hari. Kelompok B mendapat pengobatan ko…

Pengaruh Phyllanthus niruri L Sebagai Imunomodulator Terhadap Kadar IFN-g pad…

Penurunan sistem imun pada tuberkulosis paru telah lama diketahui, salah satu keberhasilan dalam penatalaksanaan TB Paru adalah meningkatkan sistem imun penderita dan menggunakan terapi standar yang telah ditetapkan oleh WHO. Ekstrak Phyllanthus niruri telah diketahui dapat meningkatkan sistem imun tubuh. Penelitian ini mencoba untuk mengetahui kadar IFN-g pada pengobatan TB dengan pemberian ek…

Effect of micronutrient supplements on influenza and other respiratory tract …

Acute respiratory tract infections (ARIs) are a leading cause of ill- health and death globally. Individual or multiple micronutrients have been shown to modulate immune function and affect the risk and severity of a number of infectious diseases. We systematically reviewed the evidence on the impact of micronutrient supplements to reduce the occurrence of ARIs and shorten the duration of ARI s…

Relative potency of proton-pum p inhibitors—comparison of effe cts on int r…

Comparative potency of proton-pump inhibitors (PPIs) is an important clinical issue. Most available trials have compared the different PPIs at one or a few selected specific dosages, making it difficult to derive quantitative equivalence dosages. Here we derived PPI dose equivalents based on a comprehensive assessment of dose-dependent effects on intragastric pH

Gastroprotective Effect of DLBS2411 Bioactive Fraction from Cinnamomum burman…

The study was carried out to evaluate the anti-ulcerative and gastroprotective effect of DLBS2411, a bioactive fraction from Cinnamomum burmannii (Nees & T. Nees) Blume, in Wistar rats (Rattus norvegicus)

Hydrogen potassium adenosine triphosphatase activity inhibition and downregul…

This study assessed the gastric acid antisecretory effect of DLBS2411 fractionated from Cinnamomum burmannii. Hydrogen potassium adenosine triphosphatase (H+/K+ ATPase) activity and its gene expression were observed, and the antioxidant activity of DLBS2411 was also investigated. Treatment of DLBS2411 decreased the level of H+/K+ ATPase messenger RNA expression on human embryonic kidney 293 cel…

BIOACTIVE FRACTION DLBS2411 FROM CINNAMOMUM BURMANNII, (NEES AND T. NEES) BLU…

Mucus therapy is one of the therapies for gastric ulcer management aside from proton pump inhibitor (PPI) and H2-blocker medication. Bioactive fraction DLBS2411 which comes from Cinnamomum burmannii has been identified as a gastric acid anti-secretory agent by inhibiting the activity of hydrogen-potassium adenosine triphosphate (H+/K+ATPase). The study was aimed to evaluate the effect of DL…

Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with…

Sucralfate, a complex of aluminium hydroxide with sulfated sucrose, forms a strong gastrointestinal tract (GIT) mucosal barrier with excellent anti-ulcer property. Because sucralfate does not undergo any significant oral absorption, sucralfate resides in the GIT for a considerable length of time. The unabsorbed sucralfate may alter the pharmacokinetics of the oral drugs by impeding its absorpti…