Once-Daily Mometasone Furoate Nasal Spray: Efficacy and Safety of a New Intra…

Once-daily mometasone furoate nasal spray (MFNS) is a new intranasal glucocorticoid for the treatment of seasonal allergic rhinitis and perennial rhinitis, and for the prophylaxis of seasonal allergic rhinitis. This paper reviews key findings from the clinical development program for MFNS, comprising more than 20 clinical trials with more than 6000 patients worldwide

Corticosteroid Treatment in Chronic Rhinosinusitis: The Possibilities and the…

Chronic rhinosinusitis (CRS), with (CRwNP) and without (CRsNP) nasal polyps, is one of the most frequent chronic inflammatory diseases, with inflammation of the nasal and paranasal sinus mucosa and sinonasal symptoms lasting for more than 12 consecutive weeks

Absence of Growth Retardation in Children With Perennial Allergic Rhinitis Af…

Intranasal corticosteroids are used widely for the treatment of allergic rhinitis because they are effective and well tolerated. However, their potential to suppress growth of pediatric subjects with allergic rhinitis continues to be a concern, particularly in light of reports of growth suppression after treatment with intranasal beclomethasone dipropionate or intranasal budesonide (see the ar…

Molecular and clinical pharmacology of intranasal corticosteroids: clinical a…

Intranasal corticosteroids (INSs) are effective treatments for allergic rhinitis, rhinosinusitis, and nasal polyposis. In recent years, increased understanding of corticosteroid and glucocorticoid receptor pharmacology has enabled the development of molecules designed specifically to achieve potent, localized activity with minimal risk of systemic exposure. Pharmacologic potency studies using…

Intranasal corticosteroids for allergic rhinitis: How do different agents com…

Intranasal steroids have proved to be an effective and safe form of therapy for allergic rhinitis. However, as the number of new glucocorticoid compounds has increased over the past decade, it has become important to consider whether significant differences exist between these agents. Pharmacologically, newer drugs such as mometasone furoate and fluticasone propionate appear to have substantia…

Efficacy and safety of mometasone furoate nasal spray in allergic rhinitis, a…

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Local and Systemic Safety of Intranasal Corticosteroids

The safety and effi cacy of intranasal corticosteroids (INCs) are well established for the management of allergic rhinitis, rhinosinusitis, and nasal polyps. As seen in numerous studies, INCs demonstrate markedly reduced systemic bioavailability compared with oral and even inhaled corticosteroids and have shown an excellent safety profi le over 3 decades of use. Nonetheless, concerns remain am…

Comparative Study On The Efficacy Of Mometasone and Fluticasone Nasal Sprays …

Allergic rhinitis is the most prevalent of allergic diseases in the world. Nasal corticosteroids are the most applicable drugs for the treatment of allergic rhinitis. In this study, we compared the efficacy of fluticasone propionate (FP) and mometasone furoate (MF) nasal sprays in the treatment of allergic rhinitis based on total nasal symptom score (TNSS) questionnaire.

Keefektifan Ekstrak Phyllanthus niruri Pada Penatalaksanaan Tuberkulosis Paru

Penurunan sistem imun pada tuberkulosis paru telah lama diketahui, salah satu keberhasilan dalam penatalaksanaan TB Paru adalah meningkatkan sistem imun penderita melalui peningkatan gizi, istirahat cukup dan farmakoterapi. Ekstrak Phyllanthus niruri telah diketahui dapat meningkatkan sistem imun tubuh. Penelitian ini mencoba untuk mengetahui manfaat ekstrak Phyllanthus niruri sebagai imunomodu…

Phyllanthus niruri as a Promising Alternative Treatment for Nephrolithiasis

In spite of considerable efforts to identify effective treatments for urolithiasis, this is a goal yet to be achieved. This review summarizes experimental and clinical data evaluating the effect of the plant Phyllanthus niruri, a plant with worldwide distribution, as a potential agent to prevent and/or to treat urolithiasis The review is based on data from the literature and on the results obta…