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Hydrogen potassium adenosine triphosphatase activity inhibition and downregul…
This study assessed the gastric acid antisecretory effect of DLBS2411 fractionated from Cinnamomum burmannii. Hydrogen potassium adenosine triphosphatase (H+/K+ ATPase) activity and its gene expression were observed, and the antioxidant activity of DLBS2411 was also investigated. Treatment of DLBS2411 decreased the level of H+/K+ ATPase messenger RNA expression on human embryonic kidney 293 cel…
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BIOACTIVE FRACTION DLBS2411 FROM CINNAMOMUM BURMANNII, (NEES AND T. NEES) BLU…
Mucus therapy is one of the therapies for gastric ulcer management aside from proton pump inhibitor (PPI) and H2-blocker medication. Bioactive fraction DLBS2411 which comes from Cinnamomum burmannii has been identified as a gastric acid anti-secretory agent by inhibiting the activity of hydrogen-potassium adenosine triphosphate (H+/K+ATPase). The study was aimed to evaluate the effect of DL…
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Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with…
Sucralfate, a complex of aluminium hydroxide with sulfated sucrose, forms a strong gastrointestinal tract (GIT) mucosal barrier with excellent anti-ulcer property. Because sucralfate does not undergo any significant oral absorption, sucralfate resides in the GIT for a considerable length of time. The unabsorbed sucralfate may alter the pharmacokinetics of the oral drugs by impeding its absorpti…
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Network pharmacology approach to investigate the molecular mechanism of DLBS2…
DLBS2411, a bioactive fraction of Cinnamomum burmannii, has been proven to exhibit its anti-ulcer properties through preclinical and clinical studies. However, the bioactive compounds, protein targets, and underlying molecular pathways are still poorly known. Therefore, network pharmacology was used in this study to understand the molecular mechanisms of DLBS2411 in treating gastritis. There…
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An Experimental Study of the Effect of Chronic Atelectasis on Pulmonary and B…
Four dogs and one patient with uncomplicated atelectasis of an entire lung were studied. Arterial oxygen saturations were nearly normal, indicating diminished flow to the atelectatic lung. Angiography confirmed this finding. "Vinyl plastic injections showed no evidence of increased bronchial collateral circulation and pathological examination of the atelectatic lung did not demonstrate any …
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Diagnosis and management of chronic cough: similarities and differences betwe…
Cough is a natural process that protects the airway. Cough can occur spontaneously or voluntarily. It is considered chronic when it is present for longer than 4 weeks in children or 8 weeks in adults. In both, chronic cough causes patient distress and increased healthcare utilization. Etiologies of pediatric chronic cough include asthma, protracted bacterial bronchitis, tracheomalacia, habit co…
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Risk Factors for Chronic Cough in Young Children: A Cohort Study
Data on the predictors of chronic cough development in young children are scarce. Our primary objective was to examine the factors associated with young children developing a chronic cough, with a focus on childcare attendance
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Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstru…
To date there are no head-to-head studies comparing different mucolytic/antioxidant agents. Considering the inconsistent evidence resulting from the pivotal studies on mucolytic/antioxidant agents tested in chronic obstructive pulmonary disease (COPD), and the recent publication of Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD (RESTORE) study, we have performed a…
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Effect of erdosteine on the rate and duration of COPD exacerbations: the REST…
Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) exacerbations and antioxidants can decrease exacerbation rates, although we lack data about the effect of such drugs on exacerbation duration. The RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) study was a prospective randomised, double-blind, placebo-controlled study, enrollin…
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Effect of Erdosteine on COPD Exacerbations in COPD Patients with Moderate Air…
The RESTORE study, a multi-national randomized, placebo-controlled study, showed that erdosteine – a muco-active antioxidant that modulates bacterial adhesiveness – reduced the rate and duration of exacerbations in moderate and severe COPD with a history of exacerbations. How much benefit patients with less severe disease experience when taking this drug remains unclear
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