Mutant Prevention Concentrations of Four Carbapenems against Gram-Negative Rods

We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ß-lactam phenotypes

Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lum…

DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus that tends to be unstable when exposed to the gastrointestinal environment. Accordingly, appropriate pharmaceutical development is needed to maximize absorption of the protein fraction in the gastrointestinal tract. In vitro, ex vivo, and in vivo stability assays were performed to study the stability of the bioactive pro…

Mechanisms of lumbrokinase in protection of cerebral ischemia

The present study was designed to explore the mechanisms involved in the anti-ischemic action of lumbrokinase (LK) in brain. The enzyme immunoassay, spectrofluorimeter and flow cytometry were used to detect the level of adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP), the Ca2+ mobilization, and human platelet surface antigen expression in o…

Improvement in Functional Status of Acute Ischemic Stroke Patients Treated wi…

DLBS0133 – a lumbrokinase fractionated from the earthworms, Lumbricus rubellus – was a promising agent in patients with ischemic stroke

Oral Fibrinolytic On The Progression Of Common Carotid Artery Intima-Media Th…

Atherosclerosis is a multifactorial and dynamic process. One of the early features of atherosclerosis is the presence of fatty streaks along the vessel wall. These fatty streaks are characterized by accumulation of lipid-filled smooth muscle cells and macrophages and fibrous tissue in focal areas of the intima

Pulmonary Embolism

HE diagnosis and treatment of pulmonary embolism demand an interdisciplinary approach, combining medical, surgical, and radiologic specialties. Despite substantial advances, mortality and recurrence rates remain high.

Ceftazidime Concentration in Gallbladder Tissue and Excretion in Bile

Ceftazidime is a new semisynthetic cephalosporin with marked resistance to ,3-lactamase, a low MIC for gramnegative bacilli, and a broad antimicrobial spectrum against Haemophilus influenzae, Enterobacter cloacae, Citrobacter freundii, Serratia marcescens, indole-positive Proteus spp., and Pseudomonas aeruginosa

Antibiotic-Induced Lipopolysaccharide (LPS) Release from Salmonella typhi: De…

It has been suggested that the antibiotic-induced release of lipopolysaccharide (LPS) is an important cause of the development of septic shock in patients treated for severe infections caused by gram-negative bacteria. b-Lactam antibiotics change the integrity of the bacterial cell envelope by binding to penicillin-binding proteins (PBP) in the membrane and thus may affect the amount of LPS …

TYPHOID FEVER

TYPHOID fever is a systemic infection with the bacterium Salmonella enterica serotype typhi. This highly adapted, human-specific pathogen has evolved remarkable mechanisms for persistence in its host that help to ensure its survival and transmission.

Prevalence of antimicrobial resistance in bacteria isolated from central ner…

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