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Efficacy and Tolerability of Combination Therapy Versus Monotherapy with Cand…
Intensive blood pressure (BP)lowering is important for the treatment of hypertension; however, it has been a challenge to achieve target BP in many patients. The purpose of this study was to explore the optimal dosage of a fixed-dose combination o candesartan cilexetil (CAN) and amlodipine besylate (AML),by examining the tolerability and efficacy of CAN/AML combination therapy compared with th…
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Evaluation of the Efficacy and Tolerability of Combination Therapy With Cande…
Blood pressure is reported to be insufficiently controlledin>50% of patients with hypertension. Guidelines for the management of hypertension recommend using drugs with different mechanisms of action when >1 agent is needed to achieve the blood pressure target. The combination of an angiotens inreceptor blocker and a calcium channel blockeris recommended asthe preferred antihypertensive medicat…
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The Relationships Between Dose and Antihypertensive Effect of Four AT1-recept…
The relationships between dose and antihypertensive effect of the first four available AT1-receptor blockers, i.e. losartan, valsartan, irbesartan and candesartan, were assessed based on data obtained from the FDA’s evaluation reports of the respective New Drug Application files. All available randomized, double-blind, placebo-controlled, parallel-group studies in adult men and women with mil…
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Sartan- AT receptor interactions: evidence for insurmountable antagonism and …
Sartans are non-peptide AT1 receptor antagonists used to treat hypertension and related pathologies. Their effects on the G protein-dependent responses of angiotensin II (Ang II) were the same in vascular tissues and in isolated cell systems. All are competitive but, when pre-incubated, they act surmountably (only rightward shift of the Ang II concentration-response curve) or insurmountably (a…
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2020 International Society of Hypertension Global Hypertension Practice Guide…
The ISH Guidelines Committee extracted evidence-based content presented in recently published extensively reviewed guidelines and tailored and standards of care in a practical format that is easy-to-use particularly in low, but also in high resource settings – by clinicians, but also nurses and community health workers, as appropriate. Although distinction between low and high resource setti…
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Effects of candesartan in patients with chronic heart failure and preserved l…
Half of patients with chronic heart failure (CHF) have preserved left-ventricular ejection fraction (LVEF), but few treatments have specific ally been assessed in such patients. In previous studies of patients with CHF and low LVEF or vascular disease and preserved LVEF, inhibition of the renin-angiotensin system is beneficial. We investigatedthe effect of addition of an angiotensin-receptor bl…
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Stroke Prevention With the Angiotensin II Type 1-Receptor Blocker Candesartan…
In elderly patients with ISH, antihypertensive treatment based on the ARB candesartan resulted in a significant 42% RR reduction in stroke in comparison with other antihypertensive treatment, despite little difference in blood pressure reduction.
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Bioequivalence study of two formulations of candesartan cilexetil tablet in h…
This study was a randomized, single- blind, two-period, cross-over study which included 24 healthy adult male and female subjects under fasting conditions. The pharmacokinetic parameters were determined based on the concentrations of candesartan (CAS 139481-59-7), using ultra-pressure high-performance liquid chromatography with a tandem mass spectrometer detector. In each of the two study perio…
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Effects of Candesartan on the Development of a New Diagnosis of Diabetes Mell…
Diabetes is a risk factor for heart failure, and both conditions are increasing. Identifying treatments that prevent both conditions will be clinically important. We previously reported that candesartan (an angiotensin receptor blocker) reduces cardiovascular mortality and heart failure hospitalizations in heart failure patients (CHARM: Candesartan in Heart Failure—Assessment of Reduction …
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Benefits and safety of candesartan treatment in heart failure are independent…
Ageing may affect drug efficacy and safety in patients with heart failure (HF). The Candesartan in Heart ailureAssessment of Reduction in Mortality and morbidity (CHARM) programme offered an opportunity to study the relationship between increasing age and the efficacy and safety of treatment in an uniquely broad spectrum of patients with symptomatic HF and either reduced or preserved left vent…
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