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Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis
COPD is incr easingly rec ognized as a le ading cause of morbidity and mortality thr oughout the world, and imposes a considerable bur den on he althcare resources. The goals of COPD management are currently to increase the time free of disease symptoms, to reduce the time spent in hospital and to improve exercise tolerance, health status and quality of life
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The risk of seizures among the carbapenems: a meta-analysis
A consensus exists among clinicians that imipenem/cilastatin is the most epileptogenic carbapenem, despite inconsistencies in the literature
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A meta-analysis of efficacy and safety of doripenem for treating bacterial in…
The aim of this article is to compare the efficacy and safety of doripenem forbacterial infections.
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Mutant Prevention Concentrations of Four Carbapenems against Gram-Negative Rods
We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ß-lactam phenotypes
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Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lum…
DLBS1033 is a bioactive protein fraction isolated from Lumbricus rubellus that tends to be unstable when exposed to the gastrointestinal environment. Accordingly, appropriate pharmaceutical development is needed to maximize absorption of the protein fraction in the gastrointestinal tract. In vitro, ex vivo, and in vivo stability assays were performed to study the stability of the bioactive pro…
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Mechanisms of lumbrokinase in protection of cerebral ischemia
The present study was designed to explore the mechanisms involved in the anti-ischemic action of lumbrokinase (LK) in brain. The enzyme immunoassay, spectrofluorimeter and flow cytometry were used to detect the level of adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′,5′-cyclic monophosphate (cGMP), the Ca2+ mobilization, and human platelet surface antigen expression in o…
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Improvement in Functional Status of Acute Ischemic Stroke Patients Treated wi…
DLBS0133 – a lumbrokinase fractionated from the earthworms, Lumbricus rubellus – was a promising agent in patients with ischemic stroke
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Oral Fibrinolytic On The Progression Of Common Carotid Artery Intima-Media Th…
Atherosclerosis is a multifactorial and dynamic process. One of the early features of atherosclerosis is the presence of fatty streaks along the vessel wall. These fatty streaks are characterized by accumulation of lipid-filled smooth muscle cells and macrophages and fibrous tissue in focal areas of the intima
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Pulmonary Embolism
HE diagnosis and treatment of pulmonary embolism demand an interdisciplinary approach, combining medical, surgical, and radiologic specialties. Despite substantial advances, mortality and recurrence rates remain high.
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Ceftazidime Concentration in Gallbladder Tissue and Excretion in Bile
Ceftazidime is a new semisynthetic cephalosporin with marked resistance to ,3-lactamase, a low MIC for gramnegative bacilli, and a broad antimicrobial spectrum against Haemophilus influenzae, Enterobacter cloacae, Citrobacter freundii, Serratia marcescens, indole-positive Proteus spp., and Pseudomonas aeruginosa
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