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Thermosensitive chitosan–Pluronic hydrogel as an injectable cell delivery c…
Injectable hydrogels have been studied for potential applications for articular cartilage regeneration. In this study, a thermosensitive chitosan–Pluronic (CP) hydrogel was designed as an injectable cell delivery carrier for cartilage regeneration. The CP conjugate was synthesized by grafting Pluronic onto chitosan using EDC/NHS chemistry. The sol–gel phase transition and mechanical prope…
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Poloxamers: A pharmaceutical excipients with therapeutic behaviors
The effect of excipients for synergistic effect or any combinational therapy is became a one of the best alternative for the dosage form development in the current research. Here we have reviewed on the different category of poloxamers as novel polymer for the drug delivery. Apart from the very good excipient properties, poloxamers showed a clinical and therapeutic uses for cure and treatmen…
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Chitosan-catechol: A polymer with long-lasting mucoadhesive properties
Numerous mucoadhesive polymers have been exploited for prolonging the residence time of formulated drugs or pharmaceuticals at specific delivery sites. However, it has been difficult to achieve satisfactory mucoadhesive properties. The two major modification strategies such as thiolation or lectin functionalization have been extensively studied, but disulfide bond reversibility in the case of t…
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A Review on Chitin and Chitosan Polymers: Structure, Chemistry, Solubility, D…
Chitin and chitosan are considerably versatile and promising biomaterials. The deacetylated chitin derivative chitosan is a useful and interesting bioactive polymer. Despite its biodegradability, it has many reactive amino side groups, which offer possibilities of chemical modifications, formation of a large variety of beneficial derivatives, which are commercially available or can be made ava…
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Lycopene and the Lung
The human lung, due to the oxidative and ozone stress to which it is exposed, is particularly vulnerable to oxidative damage. Concentrations of dietary antioxidants in the lung epithelial lining and lining fluids may provide protection against oxidative damage. A randomized clinical trial was conducted to study the effects of supplemental, carotenoid-rich vegetable juice (V-8)on lung function m…
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The Antioxidant Network and Healthy Aging
As we digest food, fight infections, and detoxify pollutants, metabolic processes generate free radicals. Most are neutralized by antioxidant enzymes, but some, like sparks from a fire, escape, and can injure our cells and the DNA they contain. Antioxidants quench these escaped free radicals, slowing the rate of accumulation of oxidative damage, and may thereby slow the rate of aging.
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Oxygenated Carotenoid Lutein and Progression of Early Atherosclerosis : The L…
Carotenoids are hypothesized to explain some of the protective effects of fruit and vegetable intake on risk of cardiovascular disease. The present study assessed the protective effects of the oxygenated carotenoid lutein against early atherosclerosis
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Tomato lycopene and its role in human health and chronic diseases
LYCOPENE IS A CAROTENOID THAT IS PRESENT IN TOMATOES, processed tomato products and other fruits. It is one of the most potent antioxidants among dietary carotenoids. Dietary intake of tomatoes and tomato products containing lycopene has been shown to be associated with a decreased risk of chronic diseases, such as cancer and cardiovascular disease. Serum and tissue lycopene levels have been f…
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Treatments for Lupus Nephritis: A Systematic Review and Network Metaanalysis
Renal benefits and the risk of herpes zoster were higher for immunosuppressive drugs versus CS. Data on relative and absolute differences are now available, which can be incorporated into patient-physician discussions related to systemic lupus erythematosus medication use
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American College of Rheumatology Guidelines for Screening, Treatment, and Man…
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns of practice and not to dictate the care of a particular patient. The ACR considers adherence to these guidelines and recommendations to be voluntary, with the ultimate determination regarding their application to be made by the physician…
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