Drug-Drug Interaction Profiles of Proton Pump Inhibitors

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EFFECT OF INTRAVENOUS OMEPRAZOLE ON RECURRENT BLEEDING AFTER ENDOSCOPIC TREAT…

After endoscopic treatment of bleeding peptic ulcers, bleeding recurs in 15 to 20 percent of patients.

Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A…

The authors present an overview of the current evidence and management recommendationsrnfor evaluation and treatment of adults with acute ischemic stroke. The intended audiences are prehospital care providers,rnphysicians, allied health professionals, and hospital administrators responsible for the care of acute ischemic stroke patientsrnwithin the first 48 hours from stroke onset. These guidel…

Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage

Purpose??he aim of this guideline is to present current and comprehensive recommendations for the diagnosis andrntreatment of aneurysmal subarachnoid hemorrhage (aSAH).

Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guid…

ICH is a serious medical condition where outcome can be impacted by early, aggressive care. The guidelines offer a framework for goal directed treatment of the ICH patient.

Nicardipine, A New Calcium Channel Blocker: Role for Vascular Selectivity

Calcium channel blockers are important drugsrnfor the treatment of chronic stable angina. However, negativerninotropic and dromotropic effects may limit their usefulnessrnin patients with atrioventricular conductionrnabnormalities or left ventricular dysfunction.

Current knowledge on the neuroprotective and neuroregenerative properties of …

Ischemic stroke is one of the leading causes of long-lasting disability and death. Two main strategies have been proposed for the treatment of ischemic stroke: restoration of blood flow by thrombolysis or mechanical thrombus extraction during the first few hours of ischemic stroke, which is one of the most effective treatments and leads to a better functional and clinical outcome. The other dir…

Application of Citicoline in Neurological Disorders: A Systematic Review

Citicoline is an abbreviation of cytidine-50 -diphosphocholine (CDP-choline). It is an endogenous chemical compound. Citicoline is globally available as a dietary supplement and in many countries as a drug. It can be bought as a tablet or an injection. In the human body, citicoline is degraded to cytidine and choline during hydrolysis and dephosphorylation. Subsequently, cytidine and choline a…

Prevalence and Characteristics of Dementia in Parkinson Disease: An 8-Year Pr…

More than three quarters of this representative PDcohort developed dementia during the 8-year study period. Early hallucinations and a kinetic-dominant PD were associated with an increased risk of dementia

Cytidine 5′-Diphosphocholine (CDP-Choline) in Stroke and Other CNS Disorders

Brain phosphatidylcholine (PC) levels are regulated by a balance between synthesis and hydrolysis. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1α/β) activate phospholipase A2 (PLA2) and PC-phospholipase C (PC-PLC) to hydrolyze PC. PC hydrolysis by PLA2 releases free fatty acids including arachidonic acid, and lyso-PC, an inhibitor of CTP-phospho…