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The Clinical Pharmacology of Non-sedating Antihistamines
We previously reported on brain H1 receptor occupancy measurements of antihistamines in human brain using [11C]doxepin and positron emission tomography (PET). We proposed the use of brain H1 receptor occupancy to classify antihistamines objectively into three categories of sedating, less-sedating, and non-sedating antihistamines according to their sedative effects. Non-sedating antihistamines a…
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Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal a…
H1-receptor antagonists are effective for the treatment of seasonal allergic rhinitis. In rare circumstances, some second-generation H1-receptor antagonists have been associated with prolongation of the corrected QT interval (QTc), thus increasing the risk of ventricular arrhythmias. Fexofenadine HCl, the carboxylic acid metabolite of terfenadine, is a new second-generation antihistamine that i…
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Efficacy and safety of loratadine plus pseudoephedrine in patients with seaso…
Antihistamines have been shown to have a varietyrnof therapeutic effects in asthma. Although nasal obstructionrnmay play an important role in modulating lower airwayrnfunction, no prior trial has used a decongestant in combinationrnwith an antihistamine in patients with allergic rhinitisrnand concomitant asthma.
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The efficacy of Rhinos® SR on nasal resistance and nasal symptoms in patient…
Rhinos® SR is a fixed combination of 5 mg loratadine and 60 mg pseudoephedrine immediate release and 60 mg pseudoephedrine sustained release. The present study was aimed to assess the efficacy of Rhinos® SR on nasal airway resistance (NAR) objectively using rhinomanometer and on nasal symptoms in patients with perennial allergic rhinitis (PAR) in a tropical country. This was a randomized, dou…
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Teknologi Sediaan Farmasi : Sustained-Release Oral
Penanganan penyakit menggunakan obat (drug treatment) merupakan bentuk terapi yang paling umum digunakan. Therapeutic efficacy obat dalam penggunaan klinis tidak hanya tergantung dari intrinsic pharmacologic activity bahan aktifnya, melainkan juga ditentukan oleh interaksi molekul obat dengan berbagai kondisi selama perjalanannya dari tempat pemberian menuju tempat kerjanya
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Loratadine Versus Cetirizine: Assessment of Somnolence and Motivation During …
This parallel-group, double-blind study compared the somnolence and motivation profiles of 2 second-generation antihistamines, loratadine and cetirizine, in pattents with allergic rhinitis.
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Bioequivalence Study of Modified Release Formulation (MRF) of Loratadine and …
The present study was conducted to find out whether the bioavailability of PT Dexa Medica’s modified-release formulation (MRF) of pseudoephedrine and loratadine fixed combination (Rhinos®SR) was comparable to that produced by the reference’s company. The pharmacokinetic parameters assessed in this study were area under the serum concentration - time curve during one dosing interval (AUC0-1…
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Efficacy of Loratadine Compared with Fexofenadine or Placebo for the Treatmen…
Compared with placebo, both loratadine and fexofenadine provided significant relief of the symptoms of SAR. At the first assessment following the first dose, however, loratadine demonstrated a significant reduction from baseline in TSS compared with fexofenadine. In addition, time-to-event analysis indicated that the reduction in symptoms occurred significantly earlier with loratadine
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Allergic rhinitis and asthma: How important is the link?
Dysfunction of the upper and lower airways frequently coexist, and they appear to share key elements of pathogenesis. Data from epidemiologic studies indicate that nasal symptoms are experienced by as many as 78% of patients with asthma and that asthma is experienced by as many as 38% of patients with allergic rhinitis. Studies also have identified a temporal relation between the onset of rh…
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Antihistamines General Statement
Antihistamines, which inhibit the effects of histamine at H1 receptors, have been classified as first generation (i.e., relatively sedating) or second generation (i.e., relatively nonsedating).
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