In Japan, hepatitis C virus (HCV) is the single most frequent cause of hepatocellular carcinoma (HCC), resulting in yearly deaths of over 30,000. Although the mechanism of how HCV induces HCC is not clear, persistent HCV infection and necro-inflammatory changes in chronic hepatitis C accelerate the development of liver cirrhosis and can event-tuate in HCC
Drug-induced liver injury (DILI) refers to liver damage caused by drugs. DILI poses a significant challenge in the development of new drugs. The management of DILI mainly involves the withdrawal of the offending drug, and there is a lack of specific therapy. This study sought to evaluate the efficacy and safety of compound glycyrrhizin (CG) injections in DILI patients. Aim To evaluate the ef…
Glycyrrhiza glabra is distributed widely throught Asia, and its dried root, Glycyrrhizae radix or licorice root, has been used as traditional drug in Eastern as well as in Western medicine, having anti-inflammatory, anti-allergic, and detoxicating effects
Glisirizin (Glycyrrhizin) sudah dikenal di Indonesia dan dunia sebagai preparat obat yang secara biokimiawi memberikan manfaat amat besar bagi perbaikan fungsi dan histologi hati. Banyak pakar bidang ilmu penyakit hati (hepatologist) telah mengakui manfaat glisirizin dalam pengobatan penyakit hati kronik. Di Indonesia, Ali Sulaiman, dkk. (2002)9 melaporkan pengalaman pemakaian SNMC® secara m…
Chronic hepatitis C is a slowly progressive liver disease that may evolve insidiously to cirrhosis and proses an increased risk of hepatocellular carcinoma (HCC).
In Japan, ALT normalization induced by long-term i.v. glycyrrhizin treatment reportedly reduces the progression of liver disease to hepatocellular carcinoma in chronic hepatitis C patients. The aim of this study was to evaluate the short-term (4-wk) feasibility and efficacy on serum ALT of three or six times per week i.v glycyrrhizin therapy in European patients
. The 10th-year rates of cumulative HCC incidence for Groups A and B were 7% and 12%, respectively, and the 15th-year rates were 12% and 25%. By Cox regression analysis, the relative risk of HCC incidence in patients not treated with SNMC (Group B) was 2.49 compared with that of patients treated with SNMC (Group A)
Majority of the patients admitted to a hospital with severe infections are initially started with intravenous medications. Short intravenous course of therapy for 2-3 days followed by oral medications for the remainder of the course is found to be beneficial to many patients. This switch over from intravenous to oral therapy is widely practiced in the case of antibiotics in many developed count…
Severe acute exacerbation (SAE) of chronic hepatitis B (CHB) may progress to liver failure with high potential mortality despite the prompt treatment with nucleos(t)ide analogs. This study aimed to evaluate the efficacy and safety of glycyrrhizin in the treatment of CHB with SAE.
This is an updated guideline for the diagnosis and management of allergic and non-allergic rhinitis, first published in 2007. It was produced by the Standards of CareCommittee of the British Society of Allergy and Clinical Immunology, using accre-dited methods. Allergic rhinitis is common and affects 10–15% of children and 26%of adults in the UK, it affects quality of life, school and work at…