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Phosphatidylserine-containing liposomes promote maximal survival of retinal n…
We investigated the systemic effect of liposomes bearing apoptotic signals on the level of inflammation and neuronal death induced by ischemia–reperfusion (IR). Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5…
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Poststroke dementia predicting survival in longterm follow-up: influence of p…
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers
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Poststroke dementia: influence of hippocampal atrophy
The prevalence of dementia is increased after stroke. Medial temporal lobe atrophy (MTLA) is associated with Alzheimer disease, and with prestroke dementia in patients who have had a stroke.
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Thermosensitive chitosan–Pluronic hydrogel as an injectable cell delivery c…
Injectable hydrogels have been studied for potential applications for articular cartilage regeneration. In this study, a thermosensitive chitosan–Pluronic (CP) hydrogel was designed as an injectable cell delivery carrier for cartilage regeneration. The CP conjugate was synthesized by grafting Pluronic onto chitosan using EDC/NHS chemistry. The sol–gel phase transition and mechanical prope…
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Poloxamers: A pharmaceutical excipients with therapeutic behaviors
The effect of excipients for synergistic effect or any combinational therapy is became a one of the best alternative for the dosage form development in the current research. Here we have reviewed on the different category of poloxamers as novel polymer for the drug delivery. Apart from the very good excipient properties, poloxamers showed a clinical and therapeutic uses for cure and treatmen…
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Chitosan-catechol: A polymer with long-lasting mucoadhesive properties
Numerous mucoadhesive polymers have been exploited for prolonging the residence time of formulated drugs or pharmaceuticals at specific delivery sites. However, it has been difficult to achieve satisfactory mucoadhesive properties. The two major modification strategies such as thiolation or lectin functionalization have been extensively studied, but disulfide bond reversibility in the case of t…
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A Review on Chitin and Chitosan Polymers: Structure, Chemistry, Solubility, D…
Chitin and chitosan are considerably versatile and promising biomaterials. The deacetylated chitin derivative chitosan is a useful and interesting bioactive polymer. Despite its biodegradability, it has many reactive amino side groups, which offer possibilities of chemical modifications, formation of a large variety of beneficial derivatives, which are commercially available or can be made ava…
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Lycopene and the Lung
The human lung, due to the oxidative and ozone stress to which it is exposed, is particularly vulnerable to oxidative damage. Concentrations of dietary antioxidants in the lung epithelial lining and lining fluids may provide protection against oxidative damage. A randomized clinical trial was conducted to study the effects of supplemental, carotenoid-rich vegetable juice (V-8)on lung function m…
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The Antioxidant Network and Healthy Aging
As we digest food, fight infections, and detoxify pollutants, metabolic processes generate free radicals. Most are neutralized by antioxidant enzymes, but some, like sparks from a fire, escape, and can injure our cells and the DNA they contain. Antioxidants quench these escaped free radicals, slowing the rate of accumulation of oxidative damage, and may thereby slow the rate of aging.
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Oxygenated Carotenoid Lutein and Progression of Early Atherosclerosis : The L…
Carotenoids are hypothesized to explain some of the protective effects of fruit and vegetable intake on risk of cardiovascular disease. The present study assessed the protective effects of the oxygenated carotenoid lutein against early atherosclerosis
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