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Clinical Outcomes and Cost Minimization with an Alternative Dosing Regimen fo…
To compare outcomes and cost for the traditional United States Food and Drug Administration–approved dosing regimen for meropenem versus an alternative dosing regimen providing similar pharmacodynamic exposure with a lower total daily dose.
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Safety Profile of Meropenem: a Review of Nearly 5,000 Patients Treated with M…
Meropenem is a parenteral carbapenem that has been used clinically since 1994. Since the first review of its safety profile in 1995, the patient database has increased substantially. This new safety analysis includes data from 46 clinical trials in hospitalized patients with serious bacterial infections. The additional data comprise patients with lower respiratory tract and intra-abdominal infe…
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Clinical Pharmacodynamics of Meropenem in Patients with Lower Respiratory Tra…
Studies of -lactam pharmacodynamics in infected patients are sparse. In this study, classification and regression tree (CART) and logistic regression analyses were used to identify which pharmacodynamic indices and magnitudes were significant predictors of meropenem efficacy for 101 adult patients with lower respiratory tract infections (LRTI). Using demographic data, a validated population p…
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An overview of the Meropenem Yearly Susceptibility Test Information Collectio…
This overview provides a summary of the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program over an 8-year period from 1997 to 2004. The evolution of the MYSTIC Program is described, as well as its design compared with other surveillance programs. In addition, the global MYSTIC Program data, published to date, are summarized, and the empiric use of carbapenems, their cu…
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Meropenem: A Review of its Use in Patients in Intensive Care
Meropenem is a carbapenem antibacterial agent that has antimicrobial activity against Gram-negative, Gram-positive and anaerobic micro-organisms. In vitro studies involving isolates from patients in intensive care units (ICUs) indicate that meropenem is more active against most Gram-negative pathogens than other comparators (including imipenem), although, compared with imipenem, meropenem is l…
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Meropenem: A Review of its Antibacterial Activity, Pharmacokinetic Propertie…
The parenteral carbapenem meropenem is relatively stable to inactivation by human renal dehydropeptidase (DHP-1) and does not require concomitant administration of a DHP-1 inhibitor such as cilastatin. It has a broad spectrum of antibacterial activity in vitro, the majority of Gram-negative, Gram-positive and anaerobic pathogens being highly susceptible to the drug. Meropenem has shown clinical…
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Clinical Effect of a Glycyrrhizin Preparation on Dermal Pruritus of Chronic M…
Patients who are undergoing maintenance hemodialysis due to chronic renal failure manifest a variety of complications. Out of such complications dermal pruritus has occurred in more than 80% of the patients and is well known to be intractable. No specific therapy for this complication has not been established. S ymptomatic treatment of different kinds are tried to indi vidual patients with unce…
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Evaluation of Effects of Drugs on Dermal Pruritus of Chronic Hemodialysis Pat…
Intractable dermal pruritus is one of the complications of chronic hemodialysis patients. Its frequency is relatively high and is said to reach more than 60% of the patients1)2). In daily practice, we often encounter patients who complain severe skin pruritus. Many ways of treatment have so far been attempted for skin pruritus but no decisive therapy has been found. The reason is considered to …
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Stronger neo-minophagen C (SNMC) for the treatment of chronic hepatitis C
Chronic hepatitis C is a slowly progressive liver disease that may elvove insidiously to cirrhosis and poses an increased risk of hepatocelullar carcinoma (HCC)
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Pruritus and Renal Failure
Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus. Topical and systemic agents as well as broadband ultraviolet phototherapy can be extremely beneficial. Gabapentin has been recently discovered…
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