Surfactant inhibition by plasma proteins: differential sensitivity of various…

Leakage of plasma proteins Into the alveolar space may inhibit surfactant function. We compared the surface properties and the sensitivity to inhlbitory proteins of different organic solvent surfactant extracts and a synthetic surfactant

The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill

The administration of intravenous fluids to maintain or increase intravascular volume is a common intervention in the intensive care unit (ICU). There has been an enduring controversy as to the impact of the choice of resuscitation fluid on patients’ outcomes [1–7]. In particular, there are no adequately powered randomized controlled trials examining the impact of resuscitation fluid cho…

Randomised trials of human albumin for adults with sepsis: systematic review …

In this analysis, human albumin solutions as part of fluid volume expansion and resuscitation for critically unwell adults with sepsis of any severity (with or without baseline hypoalbuminaemia) were not robustly effective at reducing all-cause mortality. Albumin seems to be safe in this setting, as a signal towards harm was not detected, but this analysis does not support a recommendation for use

Albumin administration improves organ function in critically ill hypoalbumine…

Albumin administration may improve organ function in hypoalbuminemic critically ill patients. It results in a less positive fluid balance and a better tolerance to enteral feeding

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A paradigm for consensus. The University Hospital Consortium guidelines for t…

The Delphi method, a systematic, literature-based consensus process, was shown to be useful in the development of complex clinical practice guidelines for the use of albumin, nonprotein colloid, and crystalloid solutions. It is anticipated that the guidelines will assist health care providers to develop local institutional policies and procedures for the appropriate and efficient use of albumin…

Review article: comparison of the pharmacokinetics, acid suppression and effi…

Proton pump inhibitors have dramatically in¯uenced the management of acid-peptic disorders in recent years. They all have a broadly similar mechanism of action and are extensively metabolized in the liver via cytochromes P450 2C19 and 3A4. There is some variation in their potential for drug interactions due to differences in enzyme inhibition. Relatively few serious adverse effects have been …

Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice

Design of freeze-drying processes is often approached with a “trial and error” experimental plan or, worse yet, the protocol used in the first laboratory run is adopted without further attempts at optimization. Consequently, commercial freeze-drying processes are often neither robust nor efficient. It is our thesis that design of an “optimized” freeze-drying process is not particularly …

Long-term management of gastroesophageal refl ux disease with pantoprazole

Gastroesophageal refl ux disease (GERD) is a chronic, relapsing disease that can progress to major complications. Affected patients have poorer health-related quality of life than the general population. As GERD requires continued therapy to prevent relapse and complications, most patients with erosive esophagitis require long-term acid suppressive treatment. Thus GERD results in a signifi …

Pharmacokinetics of Pantoprazole in Patients with Moderate and Severe Hepatic…

Patients with impaired hepatic function usually require gastric acid suppressant therapy but are at increased risk for drug interactions and may require dosage adjustments. The proton pump inhibitor pantoprazole is rapidly absorbed and eliminated, primarily by cytochrome P450 (CYP) 2C19 isozymes.