Pefloxacin Therapy for Experimental Endocarditis Caused by Methicillin-Suscep…

The therapeutic efficacy of pefloxacin in experimental endocarditis caused by methicillin-susceptible or methicillin-resistant Staphylococcus aureus was evaluated. In rabbits infected with a methicillin-susceptible strain, 4 days of pefloxacin therapy significantly reduced both the number of bacteria per gram of vegetation and the mortality rate compared with untreated controls, and pefloxacin …

Evaluation of Pefloxacin in Experimental Escherichia coli Meningitis

Pefloxacin mesylate, a new fluoroquinolone, has been shown to have a wide spectrum of activity both in vitro and in vivo (4, 8, 12, 13). Because of its excellent activity against members of the family Enterobacteriaceae and because in vitro tests may not reliably predict the bactericidal activity of a drug against meningitis (9), we evaluated the therapeutic efficacy of pefloxacin with a well-s…

Double blind randomized controlled study of once daily 400mg PefloxACIN SHORT…

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Current Trends in the Management of Typhoid Fever

Typhoid (cloudy) fever is a systemic infection, caused mainly by Salmonella typhi found only in man. It is characterized by a continuous fever for 3-4 weeks, relative bradycardia, with involvement of lymphoid tissue and considerable constitutional symptoms. In western countries, the disease has been brought very close to eradication levels.

Effects of Pioglitazone and Rosiglitazone on Blood Lipid Levels and Glycemic …

The antihyperglycemic effects of pioglitazone hydrochloride and rosiglitazone maleate are well documented. The results of clinical trials and observational studies have suggested, however, that there are individual differences in the effects of these drugs on blood lipid levels.

Efficacy and Tolerability of Pioglitazone in Patients with Type 2 Diabetes Me…

Diabetes mellitus is a debilitating disease that is estimated to affect 366 million people by the year 2030. Type 2 diabetes mellitus (T2DM) is characterized by a progressive decline in pancreatic b-cell function and increased insulin resistance, and accounts for approximately 90% of people with diabetes. Oral antihyperglycaemic agents are extensively used in the treatment of T2DM. Thiazolidine…

Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity …

We examined the effect of pioglitazone on abdominal fat distribution to elucidate the mechanisms via which pioglitazone improves insulin resistance in patients with type 2 diabetes mellitus. Thirteen type 2 diabetic patients (nine men and four women; age, 52
3 yr; body mass index, 29.0
1.1 kg/m2), who were being treated with a stable dose of sulfonylurea (n  7) or with diet alone (n  6…

Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease

Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression

Dose-dependency in pleiotropic effects of atorvastatin

Statins are recognized as the principal and most effective class of drugs for reducing serum cholesterol levels and, therefore, significantly reducing cardiovascular events and mortality. Statins may have a wide range of beneficial biological effects in addition to lipid lowering, a phenomenon commonly termed a ‘pleiotropic effect’. However, the dose-dependency of these effects remains unclear

Active Metabolite of Atorvastatin Inhibits Membrane Cholesterol Domain Format…

The advanced atherosclerotic lesion is characterized by the formation of microscopic cholesterol crystals that contribute to mechanisms of inflammation and apoptotic cell death. These crystals develop from membrane cholesterol domains, a process that is accelerated under conditions of hyperlipidemia and oxidative stress. In this study, the comparative effects of hydroxymethylglutaryl-CoA (HMG-C…