Intractable dermal pruritus is one of the complications of chronic hemodialysis patients. Its frequency is relatively high and is said to reach more than 60% of the patients1)2). In daily practice, we often encounter patients who complain severe skin pruritus. Many ways of treatment have so far been attempted for skin pruritus but no decisive therapy has been found. The reason is considered to …
Chronic hepatitis C is a slowly progressive liver disease that may elvove insidiously to cirrhosis and poses an increased risk of hepatocelullar carcinoma (HCC)
Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus. Topical and systemic agents as well as broadband ultraviolet phototherapy can be extremely beneficial. Gabapentin has been recently discovered…
In Japan, hepatitis C virus (HCV) is the single most frequent cause of hepatocellular carcinoma (HCC), resulting in yearly deaths of over 30,000. Although the mechanism of how HCV induces HCC is not clear, persistent HCV infection and necro-inflammatory changes in chronic hepatitis C accelerate the development of liver cirrhosis and can event-tuate in HCC
Drug-induced liver injury (DILI) refers to liver damage caused by drugs. DILI poses a significant challenge in the development of new drugs. The management of DILI mainly involves the withdrawal of the offending drug, and there is a lack of specific therapy. This study sought to evaluate the efficacy and safety of compound glycyrrhizin (CG) injections in DILI patients. Aim To evaluate the ef…
Glycyrrhiza glabra is distributed widely throught Asia, and its dried root, Glycyrrhizae radix or licorice root, has been used as traditional drug in Eastern as well as in Western medicine, having anti-inflammatory, anti-allergic, and detoxicating effects
Glisirizin (Glycyrrhizin) sudah dikenal di Indonesia dan dunia sebagai preparat obat yang secara biokimiawi memberikan manfaat amat besar bagi perbaikan fungsi dan histologi hati. Banyak pakar bidang ilmu penyakit hati (hepatologist) telah mengakui manfaat glisirizin dalam pengobatan penyakit hati kronik. Di Indonesia, Ali Sulaiman, dkk. (2002)9 melaporkan pengalaman pemakaian SNMC® secara m…
Chronic hepatitis C is a slowly progressive liver disease that may evolve insidiously to cirrhosis and proses an increased risk of hepatocellular carcinoma (HCC).
In Japan, ALT normalization induced by long-term i.v. glycyrrhizin treatment reportedly reduces the progression of liver disease to hepatocellular carcinoma in chronic hepatitis C patients. The aim of this study was to evaluate the short-term (4-wk) feasibility and efficacy on serum ALT of three or six times per week i.v glycyrrhizin therapy in European patients
. The 10th-year rates of cumulative HCC incidence for Groups A and B were 7% and 12%, respectively, and the 15th-year rates were 12% and 25%. By Cox regression analysis, the relative risk of HCC incidence in patients not treated with SNMC (Group B) was 2.49 compared with that of patients treated with SNMC (Group A)