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Fentanyl attenuates cardiovascular responses to tracheal extubation
We carried out a controlled, randomized, double-blind study to examine the cKccts of intravenous fentanyl ( I or 2 pg kg-') on hemodynamic changes during tracheal extubation and emergence from anesthesia in 60 ASA physical status I or I1 patients undergoing elective gynecological surgery. Anesthesia was maintained with 0.5'?'-1.5% isofluranc and 60Yn nitrous oxide (N,Oj in oxygen. Muscle relaxa…
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2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modificat…
Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in proposing the best management strategies for an individual patient with a given condition. Guidelines and their recommendations should facilitate decision making of health professionals in their daily practice. However, the final decisions concerning an individual patient must be made by the…
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Effects of Combination of Ezetimibe and Rosuvastatin on Coronary Artery Plaqu…
In approximately 80% of cardiovascular disease-related deaths, patients suffer from coronary atherosclerotic heart disease.Ezetimibe is the first intestinal cholesterol absorption inhibitor.Its combination with statins for treating coronary atherosclerotic heart disease has attracted attention worldwide
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Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Eze…
The addition of ezetimibe to statin therapy has been reported to result in increased efficacy for reduction of LDL-C levels and achievement of lipid targets, compared with monotherapy
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A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinica…
Combination therapy with ezetimibe and statins is recommended in cases of statin in tolerance or insufficiency. The objective of this study wa to compare the efficacy and safety of combination therapy with ezetimibe and rosuvastatin versus those of rosuvastatin monotherapy in patients with hypercholesterolemia
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The safety of antithrombotic therapy in patients with cerebral microbleeds an…
The impact of cerebral microbleeds on the safety of antithrombotic therapy has recently received considerable attention. We investigated the safety of antithrombotic therapy in patients with cerebral microbleeds and cardiogenic cerebral embolism caused by nonvalvular atrial fibrillation
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Clinical Pharmacology of Eptifibatide
Activation of receptor function of platelet membrane glycoprotein (GP) IIb-IIIa leads to the binding of fibrinogen and is the final common pathway to platelet aggregation. Platelet aggregates provide the structural basis for coronary thrombosis, a major cause of ischemic heart disease. GP IIb-IIIa has a narrow tissue distribution, being found only on platelets and their progenitors, and inh…
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Early initiation of eptifibatide in the emergency department before primary p…
A strategy of early initiation of eptifibatide in the ED before primary PCI for STEMI yields superior pre-PCI TIMI frame counts, reflecting epicardial flow, and superior TIMI myocardial perfusion compared with a strategy of initiating eptifibatide in the CCL without an increase in bleeding risk
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Fondaparinux in Acute Coronary Syndromes
Anticoagulant therapy is a major component in the management of acute coronary syndromes (ACS). Anticoagulant-associated adverse events like heparin-induced thrombocytopenia, bleeding complications and need of close monitoring of anticoagulation led to focus on developing agents causing anticoagulation without affecting primary haemostasis. Fondaparinux, a new-age synthetic anticoagulant, acts…
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The use of fondaparinux in pregnancy
Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in pregnancy. Although relatively safe, hypersensitivity reactions to low-molecular weight heparins (LMWHs) are frequently seen in pregnant women, with a reported 20% incidence in this cohort (Bank et al, 2003; Schindewolf et al, 2013). Fondaparinux is a synthetic pentasaccharide that has been extensively studied in…
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