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Clopidogrel Use and Long-term Clinical Outcomes After Drug-Eluting Stent Impl…
An observational study examining consecutive patients receiving intracoronary stents at Duke Heart Center, a tertiary care medical center in Durham, NC, between January 1, 2000, and July 31, 2005, with follow-up contact at 6, 12, and 24 months through September 7, 2006. Study population included 4666 patients undergoing initial percutaneous coronary intervention with BMS (n=3165) or DES (n=1501…
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Clopidogrel in non-ST-segment elevation acute coronary syndromes
Platelets play a central role in the pathophysiology of arterial thrombosis in patients with acute coronary syndrome (ACS). Aspirin is superior to placebo in preventing mortality and ischemic events in patients with ACS. Clopidogrel, when added to aspirin and given daily for up to 1 year, reduces cardiovascular death, myocardial infarction and stroke by 20% in patients presenting with ACS. The…
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Coronavirus disease-2019: is fever an adequate screening for the returning tr…
On Thursday, 30 January 2020, World Health Organization declared Coronavirus disease-2019 (COVID-2019) a Public Health Emergency of International Concern. Since its identification in late December 2019 in Wuhan, Hubei Province, People’s Republic of China, the number of cases imported into other countries is increasing, and the epidemiological map is changing rapidly. On the other hand, bod…
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Mechanical Ventilation: Settings and Basic Modes
Mechanical ventilation is a lifesaving tool utilized in the intensive care unit, during surgical procedures requiring general anesthesia, and in long-term acute care settings to assist patients who require additional respiratory support. Invasive mechanical ventilation requires an endotracheal tube that is connected to a ventilator, whereas non-invasive ventilation delivers oxygen through a …
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Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea it…
DLBS1442, a proprietary and standardized semipolar bioactive extract of the fruit Phaleria macrocarpa, is preclinically proven to have anti-inflammatory properties. The current clinical study evaluated the efficacy and safety of DLBS1442 in alleviating symptoms of premenstrual syndrome and primary dysmenorrhea
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Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological ef…
Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macrocarpa especially in Asia reflects the usage of diverse extraction techniques, particularly modern a…
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Effectivity and safety of mahkota dewa fruit extract compared to meloxicam (p…
Osteoarthritis (OA) is the most common musculoskeletal disease. World Health Organization (WHO) estimates that 10% of the aged over 60 year population have this disease. The aim of OA treatment is to reduce pain, which is the most OA patients chief complaint. People in Indonesia are very interested in use of herbal therapies from original traditional plant to treat pain now, one of the tradit…
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Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined…
The aim of this paper is to evaluate the efficacy and safety of DLBS3233, a novel bioactive fraction derived from Cinnamomum burmanii and Lagerstroemia speciosa, in improving insulin resistance and preserving β-cell performance in patients with impaired glucose tolerance (IGT).
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DLBS3233 extract, a novel insulin sensitizer with negligible risk of hypoglyc…
DLBS3233 is a standardized extract combination of two Indonesian herbals (Lagerstroemia speciosa L. and Cinnamomum burmanii L.) developed by a patented extraction-technology. DLBS3233 has been proven pre-clinically to have a glucose lowering activity. This Phase 1 clinical study evaluated the safety of DLBS3233 in comparison with the negative-control and pioglitazone 30 mg (active control) in h…
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Mechanisms Involved in the Relationship between Vitamin D and Insulin Resista…
Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extraskeletal activity. In this context, vitamin D seems to be involved in infections autoimmune diseases, cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D) levels appe…
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