Pharmacology of anticoagulants used in the treatment of venous thromboembolism

Anticoagulant drugs are the foundation of therapy for patients with VTE. While effective therapeutic agents, anticoagulants can also result in hemorrhage and other side effects. Thus, anticoagulant therapy selection should be guided by the risks, benefits and pharmacologic characteristics of each agent for each patient. Safe use of anticoagulants requires not only an in-depth knowledge of thei…

Diagnosis dan Tatalaksana Deep Vein Thrombosis

Deep vein thrombosis (DVT) adalah bekuan darah di vena dalam yang sebagian besar tersusun atas fibrin, sel darah merah, serta sebagian kecil komponen leukosit dan trombosit. Diagnosis DVT ditegakkan berdasarkan gejala klinis dan pemeriksaan penunjang berupa laboratorium dan radiologi. Penatalaksanaan DVT dapat berupa terapi non-farmakologis, farmakologis, ataupun pembedahan

Fondaparinux Sodium Compared With Low-Molecular-Weight Heparins for Periopera…

Fondaparinux sodium has been compared with low-molecular-weight heparins (LMWH) in randomized controlled trials for perioperative surgical thromboprophylaxis. However, the results from these studies are inconsistent in terms of efficacy and safety to reach a clinical decision. The objective of this study was to systematically review the randomized controlled trials comparing the efficacy and sa…

Fondaparinux or Enoxaparin for the Initial Treatment of Symptomatic Deep Veno…

The current standard initial therapies for deep venous thrombosis are low-molecular-weight heparin and unfractionated heparin. In a dose-ranging study of patients with symptomatic deep venous thrombosis, fondaparinux had efficacy and a safety profile similar to those of low-molecular-weight heparin (dalteparin)

Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes

The combined use of anticoagulants, antiplatelet agents, and invasive coronary procedures reduces ischemic coronary events but also increases bleeding in patients with acute coronary syndromes. We therefore assessed whether fondaparinux would preserve the anti-ischemic benefits of enoxaparin while reducing bleeding

Pengaruh Phyllanthus Niruri L sebagai imunomodulator terhadap kadar IFN-g pad…

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The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa

The aqueous extract of Nigella sati
a (N. sati
a) was investigated for anti-inflammatory, analgesic and antipyretic activities in animal models. The extract has an anti-inflammatory effect demonstrated by its inhibitory effects on Carrageenan induced paw edema. It also produced significant increase in the hot plate reaction time in mice indicating analgesic effect. However, N. sati
a crude s…

Symptomatic treatment of acute tonsillopharyngitis patients with a combinatio…

Acute tonsillopharyngitis is characterized by tonsil or pharyngeal inflammation and mostly is a virus in origin; thus, treatment that covers both the inflammation and inadequate immune response against the pathogenic organism is needed. NSPN extract containing Nigella sativa and Phyllanthus niruri extracts has both antiinflammatory and immunomodulatory effects.

Therapeutic Applications of Citicoline and Piracetam as Fixed Dose Combination

Combination of citicoline and piracetam is available in market as fixed dose combination in film coated tablet with dose of citicoline 500 mg and piracetam 800 mg. It has been approved by DCGI in the year 2010. This combination is chemically and pharmalogically safe.

Piracetam in the Treatment of Acute Stroke

The neuroprotective properties of the nootropic agent piracetam together with reported hemorrheologic and antithrombotic effects provided the rationale for the evaluation of piracetam in acute stroke. Pilot studies showed an increase in compromised regional cerebral blood flow and Improvement in motor function, aphasia and level of consciousness